摘要
特发性肺纤维化(IPF)是一种慢性间质性肺病,成纤维细胞、巨噬细胞和淋巴细胞在其中发挥重要作用。CD27/CD70轴通过分子通路与肺部免疫细胞的协同作用影响肺纤维化区域的免疫微环境,并在肺纤维化早期起到一定抑制作用,有望成为IPF免疫治疗的新靶点。
Idiopathic pulmonary fibrosis(IPF)is a chronic interstitial lung disease marked by the significant involvement of fibroblasts,macrophages and lymphocytes.The CD27/CD70 axis is pivotal in shaping the immune microenvironment present in the fibrotic aeras of lungs.This mentioned interaction involves molecular pathways that work in tandem with lung immune cells,particularly exerting a suppressive influence in the early phases of pulmonary fibrosis.Consequently,the CD27/CD70 axis presents a promising new target for immunotherapy in IPF.
作者
徐云聪
郑金旭
XU Yuncong;ZHENG Jinxu(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China)
出处
《基础医学与临床》
CAS
2024年第8期1170-1174,共5页
Basic and Clinical Medicine
基金
镇江市重大(社会发展)项目(SH2018048)
苏州市社会发展(民生医疗)项目(SYSD2020010):江苏大学医教协同创新基金(JDYY2023034)。
