SphK/S1P在心血管疾病中的作用

Role of SphK/S1P in cardiovascular diseases

磷酸鞘氨醇(S1P)是一种活性高的膜磷脂类代谢物,对心血管系统具有重要的生理作用。鞘氨醇激酶(SphK)是一种脂肪酶,对维持体内S1P水平的稳定非常重要。S1P通过催化调节与细胞表面的G蛋白偶联受体(S1PR1-5)的结合,从而在心血管疾病中发挥不同的生理学效应,如参与调控动脉粥样硬化、心肌缺血再灌注损伤、心肌梗死、心力衰竭等疾病的发生发展,维持血管内皮细胞屏障功能,保护内皮糖萼层,白细胞黏附以及炎性反应等生理病理过程。

Sphingosine-1-phosphate(S1P)is a highly active membrane phospholipid metabolite with important physiological roles in the cardiovascular system.Sphingosine kinase(SphK)is a lipase that is important for maintaining stable S1P levels in vivo.S1P exerts different physiological effects in cardiovascular diseases by catalytically regulating the binding of S1P to G protein-coupled receptors(S1PR1-5)on the cell surface,thus exerting different physiological effects in cardiovascular diseases.For example,they are involved in regulating the development of diseases such as atherosclerosis,myocardial ischemia-reperfusion injury,myocardial infarction,heart failure and other diseases,maintaining the barrier function of vascular endothelial cells,protecting the endothelial glycocalyx layer,leukocyte adhesion,inflammatory reactions and other pathophysiologic processes.