中药单体联合化学药抗胶质母细胞瘤纳米制剂研究进展

Nano-preparation of traditional Chinese medicine monomer combined with chemotherapeutic drugs against glioblastoma

胶质母细胞瘤(glioblastoma multiforme,GBM)是一种高度侵袭性和破坏性的脑肿瘤,但单一化疗药物不良反应多、易产生耐药性,临床预后不良,复发率高。研究表明,中药单体联合化学药在治疗GBM中能提高药物疗效、减少化学药的耐药性和不良反应,显现出较好的应用前景。中药单体与化学药联用治疗GBM的给药途径涵盖口服、鼻腔给药、注射等多种途径,剂型涉及脂质体、纳米粒、纳米胶束等多种纳米制剂形式。总结了中药单体联合化药抗GBM的给药途径和纳米制剂的类型,以期为中药单体联合化药抗GBM的纳米制剂的研究与应用提供参考。

Glioblastoma multiforme(GBM)is a highly aggressive and destructive brain tumor,but a single chemotherapeutic agent has many adverse effects,is prone to drug resistance,has a poor clinical prognosis,and has a high recurrence rate.Studies have shown that the combination of traditional Chinese medicine(TCM)monomers with chemotherapeutic drugs in the treatment of GBM can improve drug efficacy and reduce the resistance and side effects of chemotherapeutic drugs,showing a better application prospect.The routes of administration of TCM monomers in combination with chemotherapeutic drugs for the treatment of GBM cover oral,nasal,and injection routes,and the dosage forms involve liposomes,nanoparticles,nanocolloids,and other nano preparation forms.This paper summarizes the routes of administration and the types of nano formulations of TCM monomers combined with chemotherapeutic drugs for anti-GBM.The purpose of this study is to provide a reference for the research and application of nanoformulations of TCM monomers in combination with chemotherapeutic agents for the treatment of GBM.