基于化学成分、药理作用及网络药理学的血府逐瘀胶囊质量标志物(Q-Marker)预测

Prediction of quality markers of Xuefu Zhuyu Capsule based on chemical composition, pharmacological action and network pharmacology

血府逐瘀胶囊(Xuefu Zhuyu Capsule,XZC)是一种传统中药制剂,具有活血化瘀、舒筋活络的作用。在临床实践中被广泛用于治疗瘀血相关疾病。此外XZC还具有一定的抗炎和抗氧化活性。通过对近年来XZC中所含化学成分及其药理作用进行总结,基于中药质量标志物(quality marker,Q-Marker)核心理论,应用网络药理学方法分析预测XZC的Q-Marker。结果表明芍药苷、阿魏酸、甘草苷、甘草酸、苦杏仁苷可作为XZC的Q-Marker,为XZC的后续研究提供质量控制参考。

Xuefu Zhuyu Capsule(血府逐瘀胶囊,XZC)is a traditional Chinese medicine(TCM)preparation that has the effects of promoting blood circulation,removing blood stasis,and relaxing tendons and activating collaterals.It is widely used in clinical practice to treat blood stasis related diseases.In addition,XZC also has certain anti-inflammatory and antioxidant activities.By summarizing the chemical components and pharmacological effects of XZC in recent years,based on the core theory of TCM quality marker(Q-Marker),network pharmacology methods are applied to analyze and predict the Q-Marker of XZC.The results indicated that paeoniflorin,ferulic acid,liquiritin,glycyrrhizic acid,and amygdalin can serve as Q-Marker for XZC,providing quality control references for subsequent research on XZC.