苍术中有效成分抗肿瘤作用机制研究进展

Mechanism of anti-tumor effect of active ingredients of Atractylodis Rhizoma

苍术为菊科植物茅苍术Atractylodes lancea或北苍术A.chinensis的干燥根茎。具有燥湿健脾、祛风散寒之功效,苍术作为一种传统的中药材,具有多种药理作用,其中抗肿瘤作用受到了广泛的关注。现代研究证明,苍术中萜类、多糖类等化合物能抑制肿瘤细胞的增殖、黏附、侵袭和转移,诱导细胞凋亡和自噬,抑制肿瘤血管生成,阻滞细胞周期和信号转导,还可通过提高机体免疫功能,抑制肿瘤的发生发展,对不同类型的恶性肿瘤均有良好的拮抗作用,具有多成分、多靶点、多通路的特点。因此,通过近年来国内外相关文献,综述了苍术的化学成分组成以及活性成分的抗肿瘤作用机制,以期为苍术抗肿瘤的深入研究和新药开发提供参考依据。

Cangzhu(Atractylodis Rhizoma)is the dried rhizome of Atractylodes lancea(Thunb.)DC.or Atractylodes chinensis(DC.)Koidz.of Asteraceae.It has the efficacy of drying dampness,strengthening the spleen,dispelling wind and dispersing cold.Atractylodis Rhizoma,as a traditional Chinese herbal medicine,has various pharmacological effects,among which the antitumor effect has received wide attention.Modern research has proved that flavonoids,terpenoids,polysaccharides and other compounds of Atractylodis Rhizoma can inhibit the proliferation,adhesion,invasion and metastasis of tumor cells,induce apoptosis and autophagy,inhibit tumor angiogenesis,and block cell cycle and signaling.Inhibit tumor development by improving the immune function of the body,and have good antagonistic effects on different types of malignant tumors,with the characteristics of multi-component,multi-target and multi-pathway.Therefore,this paper reviews the chemical composition of Atractylodis Rhizoma and the anti-tumor effect mechanism of the active ingredients through the relevant literature at home and abroad in recent years,with a view to providing reference basis for the in-depth study of Atractylodis Rhizoma’s anti-tumor and the development of new drugs.