光动力治疗在外阴硬化性苔藓中的应用

Application of photodynamic therapy in vulvar lichen sclerosus

目的 探究光动力疗法(PDT)在女性外阴硬化性苔藓治疗中的效果。方法 选取2021年1月~2023年6月因外阴硬化性苔藓就诊于潍坊市人民医院的患者86例,随机分为两组,结合患者治疗前后的临床症状及体征,统计并分析糠酸莫米松乳膏和PDT在女性外阴硬化性苔藓治疗中的效果。结果 分别对治疗前糠酸莫米松组和PDT组患者的临床症状及体征进行评分,差异无统计学意义(P>0.05),对两组患者治疗后3个月的临床症状及体征进行评分比较,PDT组患者的各项评分均低于糠酸莫米松组,差异有统计学意义(P<0.05);比较两组患者的治疗总有效率,糠酸莫米松组为74.4%,PDT组为90.7%,差异有统计学意义(P=0.047)。评估两组患者治疗后不良反应的发生率,糠酸莫米松组的发生率高于PDT组,差异有统计学意义(P=0.001)。结论 PDT具有疗效好、创伤小、不良反应少、治疗后不易复发等优点,可作为女性外阴硬化性苔藓的治疗方法。

Objective To explore the effect of photodynamic therapy in the treatment of vulvar lichen scle-rosus.Methods s From January 2021 to June 2023,86 patients with vulvar sclerosing lichen in Weifang People's Hospital were randomly divided into two groups.Combined with the clinical symptoms and signs of patients before and after treat-ment,the effects of mometasone furoate cream and photodynamic therapy on female vulvar sclerosing lichen were statisti-cally analyzed.Results The clinical symptoms and signs of the two groups were scored before treatment,and the dffer-ence was not statistically significant(P>0.05).The clinical symptoms and signs of the two groups were scored three months after treatment,and the scores of the patients in the photodynamic therapy group were lower than those in the mo-metasone furoate group,with statistical significance(P<0.05).The total effective rate of the two groups was 74.4%in mometasone furoate group and 90.7%in PDT group,and the difference was statistically significant(P=0.047).The in-cidence of adverse reactions after treatment was evaluated between the two groups.The incidence of mometasone furoate group was higher than that of PDT group,and the difference was statistically significant(P=0.001).Conclusion Pho-todynamic therapy has the advantages of good curative effect,less trauma,less adverse reactions and less recurrence after treatment,and can be used as a treatment for female vulvar sclerosing lichen.