摘要
目的:探讨老年脑梗死患者血清抗心磷脂抗体(ACA)、抗β2糖蛋白1抗体(抗β2GP1)、同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)水平变化及其与疾病严重程度的关系。方法:选取148例老年脑梗死患者为观察组,根据神经功能缺损(NDS)评分分为轻度组(n=30)、中度组(n=32)及重度组(n=86);另选同期76名体检健康老年人为对照组。比较观察组和对照组及观察组不同病情程度患者的血清ACA、抗β2GP1、Hcy、hs-CRP水平,分析其与疾病严重程度的关系。结果:观察组患者血清ACA、抗β2GP1、Hcy、hs-CRP水平高于对照组(P<0.05)。不同病情程度脑梗死患者血清ACA、抗β2GP1、Hcy、hs-CRP水平比较:重度组>中度组>轻度组(P<0.05)。相关性分析显示,血清ACA、抗β2GP1、Hcy、hs-CRP水平与老年脑梗死患者病情严重程度均呈正相关关系(r=0.636、0.614、0.563、0.571,P<0.05)。ROC曲线分析显示,血清ACA对轻中度与重度的区分有更高的鉴别价值(P<0.05),敏感度和特异性分别为90.70%、87.10%。结论:老年脑梗死患者血清ACA、抗β2GP1、Hcy、hs-CRP水平均升高,且与病情严重程度正相关,可作为鉴别脑梗死严重程度的有效指标。
Objective:To explore the changes of serum anticardiolipin antibody(ACA),anti-β2 glycoprotein 1 antibody(anti-β2GP1),homocysteine(Hcy)and hypersensitive C-reactive protein(hs-CRP)levels in elderly patients with cerebral infarction and the relationship with disease severity.Methods:148 elderly patients with infarction were selected as the observation group.According to the neurological deficit score(NDS),the above patients were classified into mild group(n=30),moderate group(n=32)and severe group(n=86).76 healthy elderly people who underwent physical examination were included in control group.The levels of serum ACA,anti-β2GP1,Hcy and hs-CRP were compared in groups,and the expression characteristics of the above serum factors in elderly patients with cerebral infarction and their relationship with disease progression were analyzed.Results:Compared with control group,the levels of serum ACA,anti-β2GP1,Hcy and hs-CRP in observation group were higher(P<0.05).Serum ACA,anti-β2GP1,Hcy and hs-CRP levels of elderly patients with cerebral infarction in severe group were higher than those in moderate group(P<0.05),and the levels were higher in moderate group than those in mild group(P<0.05).Correlation analysis showed that serum ACA,anti-β2GP1,Hcy and hs-CRP were positively correlated with the severity of elderly patients with cerebral infarction(r=0.636,0.614,0.563,0.571,P<0.05).ROC curve analysis showed that serum ACA had a more obvious distinguishing value for the distinction between mild-to-moderate disease and severe disease,and its sensitivity and specificity were 90.70%and 87.10%,respectively.Conclusion:The levels of serum ACA,anti-β2GP1,Hcy and hs-CRP are elevated in elderly patients with cerebral infarction,and are positively correlated with disease severity.They are all highly effective in distinguishing the severity of cerebral infarction.
作者
武岳
席光明
屈斐
WU Yue;XI Guang-ming;QU Fei(Department of Neurology,Shangluo Central Hospital,Shangluo 726000,Shaanxi,China)
出处
《川北医学院学报》
CAS
2024年第7期908-912,共5页
Journal of North Sichuan Medical College
基金
陕西省重点研发计划项目(2019JM7512)。
关键词
脑梗死
抗心磷脂抗体
抗Β2糖蛋白1抗体
同型半胱氨酸
超敏C反应蛋白
Cerebral infarction
Anti-cardiolipin antibody
Anti-β2 glycoprotein 1 antibody
Homocysteine
Hypersensitive C-reactive protein