HPV经精子传播及其对早期胚胎发育的影响

HPV Transmission through Sperm and Its Impact on Early Embryonic Development

人乳头瘤病毒(human papilloma virus,HPV)感染是全球常见的性传播疾病之一,与多种器官的肿瘤发生有关。近年来,HPV经生殖细胞传播及其对早期胚胎发育的潜在影响备受关注。研究表明,HPV感染可能影响男性精子质量,导致不育,同时可能干扰胚胎发育,增加自然流产的风险,并对辅助生殖技术的妊娠结局产生不良影响。综述HPV经精子传播及其对早期胚胎发育影响的研究进展,旨在深入理解HPV对生育健康的潜在威胁,并为临床实践和进一步研究提供参考。

Human papilloma virus(HPV)infection is one of the most common sexually transmitted diseases,which is associated with the development of tumors in multiple organs.In recent years,the impact of HPV infection on fertility has garnered significant attention,particularly its vertical transmission through germ cells and potential effects on early embryonic development.Studies have shown that HPV infection may affect sperm quality,leading to infertility,and may also interfere with embryonic development,increasing the risk of spontaneous abortion and adversely affecting pregnancy outcomes in assisted reproductive technology.This review summarizes the research progress on the vertical transmission of HPV through sperm cells and its impact on early embryonic development,to deeply understand the potential threat of HPV to reproductive health and to provide references for clinical practice and further research.