常用亲电N-F氟化试剂及其氟化机理研究进展

Research Progress of Common Electrophilic N-F Fluorination Reagents and Their Fluorination Mechanism

亲电氟化反应是将氟选择性引入有机化合物的最直接和最有用的方法之一。N-F类亲电氟化试剂彻底改变了将氟原子掺入重要的医药和农业化学品底物中的方法。自从最早的N-F氟化试剂在20世纪90年代商业化以来,它们的合成及反应活性已经被广泛地研究。重点介绍了几种常用的N-F氟化试剂,并对相对氟化能力及氟化机理进行了讨论。

Electrophilic fluorination is one of the most direct and useful ways to selectively introduce fluorine into organic compounds.The N-F class of electrophilic fluorination reagents revolutionized the incorporation of fluorine atoms into substrates of important medicine and agricultural chemicals.Since the first N-F fluorination reagents were commercialized in the 1990s,their synthesis and reactivity have been extensively studied.In this paper,several commonly used N-F fluorination reagents are introduced,and the relative fluorination ability and fluorination mechanism are discussed.