基于甘草次酸的肝癌靶向纳米递送系统研究进展

Research Progress of Targeted Nano-delivery System for Hepatocellular Carcinoma Based on Glycyrrhetinic Acid

靶向性纳米药物递送系统(TNDDS)在肝癌药物递送方面具有显著优势,借助配体-受体作用靶向肿瘤部位。TNDDS可以减少达到治疗指数所需的药物量,改善药代动力学和生物分布,并且可以在单次给药后延长药物释放数天。近年来,甘草次酸(GA)作为一种高效的肝癌靶向配体引起了人们的广泛关注。GA的优越性主要体现在其兼具高效肝癌靶向能力、抗肿瘤活性和良好的生物相容性。基于GA的肝癌纳米递送系统具有很高的位点特异性和治疗效率,可以递送化疗药物或基因药物。本文重点介绍GA作为肝癌靶向配体的基础理论及基于GA的纳米递送系统在肝癌治疗方面的研究情况。通过本文的回顾总结,希望相关研究者能对GA基肝癌靶向递送系统的现状有一个系统的认知,为新的递送系统的开发提供参考。

Targeted nano-drug delivery system(TNDDS)offers prominent advantages in drug delivery for treatment of hepatocellular carcinoma,targeting the tumor site via ligand-receptor interaction.TNDDS reduces the dosage of drug to fulfill the therapeutic index requirement,improving pharmacokinetics and biodistribution.Besides,it can sustain drug release for several days after single-dose administration.In recent years,glycyrrhetinic acid(GA)attracts much attention as a highly efficient ligand targeting to liver tumor.The superiority of GA is mainly reflected in its combination of efficient liver tumor targeting,superior anti-tumor activity and favorable biocompatibility.GA-based TNDDS to liver tumor possesses high site-specificity and therapeutic efficiency for chemotherapeutic drugs or genetic materials delivering.This paper focuses on the basic theory of GA as a ligand targeting to liver tumor and the researches advances in the development of GA-based nano-delivery systems.Through the review and summary in this paper,it is expected to systematically present current progress of GA-based liver tumor TNDDS for interested researchers,and provide references for the development of new delivery systems.