老年肺癌患者化疗前衰弱状况及其对短期不良结局事件的影响研究

Status of Pre-chemotherapy Frailty in Patients with Elderly Lung Cancer and Its Effect on Short-Term Adverse Outcome Events

目的调查老年肺癌患者化疗前衰弱状况及其对短期不良结局事件的影响。方法采用便利抽样法选取2020年6月—2021年12月首都医科大学附属北京友谊医院收治的204例老年肺癌患者为研究对象,收集患者临床资料,根据患者化疗前衰弱状况将其分为衰弱组和非衰弱组。对患者随访12个月,记录患者不良结局事件(包括化疗期间毒副作用以及随访期间死亡、失能、非计划性住院)发生情况。结果化疗前衰弱患者85例,非衰弱患者119例。衰弱组化疗后衰弱发生率高于非衰弱组(P<0.05)。衰弱组化疗期间毒副作用数量多于非衰弱组,毒副作用分级高于非衰弱组(P<0.05)。随访期间衰弱组死亡率高于非衰弱组(P<0.05)。衰弱组随访期间失能情况重于非衰弱组,非计划性住院率高于非衰弱组(P<0.05)。结论老年肺癌患者化疗前衰弱已较普遍,化疗后衰弱发生率进一步增加。化疗前衰弱的老年肺癌患者化疗期间毒副作用多且严重,随访期间死亡风险高、失能情况严重、非计划性住院率高。

Objective To investigate the status of pre-chemotherapy frailty in patients with elderly lung cancer and its effect on short-term adverse outcome events.Methods A total of 204 elderly lung cancer patients admitted to Beijing Friendship Hospital Affiliated to Capital Medical University from June 2020 to December 2021 were selected as the research subjects through convenience sampling method.The clinical data of the patients were collected,the patients were divided into frailty group and non-frailty group based on the status of pre-chemotherapy frailty.The patients were followed up for 12 months,and the occurrence of adverse outcome events(including toxic side effects during chemotherapy,as well as death,disability,and unplanned hospitalization during the follow-up period)were recorded.Results There were 85 patients with pre-chemotherapy frailty,119 patients without frailty.The incidence of post-chemotherapy frailty in the frailty group was higher than that in the nonfrailty group(P<0.05).The number of toxic side effects during chemotherapy in the frailty group was higher than that in the nonfrailty group,and the grade of toxic side effects was higher than that in the non-frailty group(P<0.05).The mortality rate during the follow-up period in frail group was higher than that in non-frail group(P<0.05).During the follow-up period,the disability situation in frail group was more severe than that in non-frail group,and the unplanned hospitalization rate was higher than that in the non-frail group(P<0.05).Conclusion Pre-chemotherapy frailty is more common in elderly lung cancer patients,and the incidence of post-chemotherapy frailty is further increasing.Elderly lung cancer patients with pre-chemotherapy frailty have more and more serious toxic side effects during chemotherapy,as well as mortality,disability,and unplanned hospitalization during the follow-up period.