辅助生殖技术治疗期间患者焦虑抑郁患病率的meta分析

Prevalence of the anxiety and depression of patients during the treatment of assisted reproductive technology:a meta-analysis

目的:对接受辅助生殖技术患者治疗期的焦虑、抑郁患病率进行meta分析。方法:计算机检索PubMed、The Cochrane Library、EMbase、Web of Science、CBM、CNKI和万方数据库,搜集有关行辅助生殖技术患者治疗期焦虑、抑郁患病现状的横断面研究,检索时限均从建库至2023年4月4日。由2位研究员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 15.1软件进行meta分析。结果:共纳入27个横断面研究,焦虑研究纳入9876人,焦虑人数2145人;抑郁研究纳入13207人,抑郁人数3562人。meta分析结果显示,行辅助生殖技术男性焦虑患病率为13%,抑郁患病率为28%;女性焦虑患病率为32%,抑郁患病率为36%。亚组分析结果显示,轻度、中度、重度焦虑患病率分别为21.0%、4.0%和0.6%,轻度、中度、重度、极重度抑郁患病率分别为28.0%、11.0%、1.0%和0.3%。华南、西北、华中、西南、华北和华东地区行辅助生殖技术患者焦虑患病率分别为24%、21%、34%、10%、30%和29%,抑郁患病率分别为39%、41%、38%、27%、29%和33%。结论:现有证据表明行辅助生殖技术患者治疗期间焦虑、抑郁患病率均较高。受纳入研究数量和质量的限制,上述结论尚需更多高质量研究予以证实。

Objective:To systematically evaluate the prevalence of the anxiety and depression of patients during the treatment of assisted reproductive technology.Methods:The databases,such as PubMed,Cochrane Library,EMBASE,Web of Science,CBM,CNKI and WanFang,from the inception dates to April 4,2023 were searched by computer to collect the cross-sectional studies on the current status of the anxiety and depression of the patients during the treatment of assisted reproductive technology.Two researchers selected the literature,extracted the data and evaluated the risk of bias of the included studies independently.The meta-analysis was performed using Stata 15.1.Results:A total of 27 cross-sectional studies were included in for meta-analysis,with a total sample size of 9876 with anxiety and13,207 patients with depressed.Meta analysis showed that the prevalence of the anxiety and the depression of the male patients were 13%and 28%,and the prevalence of the anxiety and the depression of the female patients were 32%and36%.The subgroup analysis showed that the prevalence of the mild,moderate,and severe anxiety of the patients were21.0%,4.0%,and 0.6%,respectively,and the prevalence of the mild,moderate,severe and very severe depression of the patients were 28.0%,11.0%,1.0%and 0.3%,respectively.The prevalence of the anxiety of the patients with assisted reproductive technology in South China,Northwest China,Central China,Southwest China,North China and East China were 24%,21%,34%,10%,30%and 29%,respectively,and the prevalence of the depression of the patients with assisted reproductive technology in South China,Northwest China,Central China,Southwest China,North China and East China were 39%,41%,38%,27%,29%and 33%,respectively.Conclusion:The evidences available showed that the prevalence of anxiety and depression of the patients during the treatment of assisted reproductive technology is still at a high level,and which should be confirmed by more high-quality studies because of the limited of this meta-analysis by the quantity and the quality of the included studies.