瑞芬太尼复合丙泊酚靶控输注麻醉方案对肝部分切除术患者麻醉效果及创伤反应的影响

Effects of remifentanil combined with propofol target controlled infusion anesthesia scheme on anesthetic effect and traumatic responses in patients undergoing partial hepatectomy

目的探讨瑞芬太尼复合丙泊酚靶控输注麻醉方案对肝部分切除术患者麻醉效果及创伤反应的影响。方法选取2020年12月至2022年12月收治的80例行肝部分切除术患者作为研究对象,根据麻醉方案不同将其分为对照组和观察组,各40例。对照组采用常规麻醉方案,观察组采用瑞芬太尼复合丙泊酚靶控输注麻醉方案。比较两组的血流动力学指标、创伤反应指标及苏醒情况。结果手术10 min(T_(1))、术毕(T_(2)),观察组的心率(HR)、平均动脉压(MAP)高于对照组(P<0.05)。T_(1)、T_(2),观察组的5-羟色胺(5-HT)、前列腺素E_(2)(PGE_(2))水平低于对照组(P<0.05)。拔管后即刻、拔管后15 min,观察组的改良警觉/镇静评估法(OAA/S)评分高于对照组(P<0.05)。结论瑞芬太尼复合丙泊酚靶控输注麻醉方案能提高肝部分切除术患者麻醉效果,减轻创伤反应,利于术后苏醒。

Objective To investigate the effects of remifentanil combined with propofol target controlled infusion anesthesia scheme on anesthetic effect and traumatic responses in patients undergoing partial hepatectomy.Methods A total of 80 patients who underwent partial hepatectomy from December 2020 to December 2022 were selected as the research objects.According to different anesthesia schemes,the patients were divided into control group and observation group,with 40 cases in each group.The control group was given conventional anesthesia,and the observation group was given remifentanil combined with propofol target controlled infusion anesthesia.The hemodynamic indexes,traumatic response indexes and recovery of the two groups were compared.Results At 10 min after operation(T_(1))and at the end of operation(T_(2)),the heart rate(HR)and mean artery pressure(MAP)in the observation group were higher than those in the control group(P<0.05).At T_(1) and T_(2),the levels of 5-hydroxytryptamine(5-HT)and prostaglandin E_(2)(PGE_(2))in the observation group were lower than those in the control group(P<0.05).Immediately after extubation and 15 min after extubation,the modified Observer's Assessment of Alertness/Sedation(OAA/S)score of the observation group was higher than that of the control group(P<0.05).Conclusion The remifentanil combined with propofol target controlled infusion anesthesia scheme can improve the anesthesia effect of patients undergoing partial hepatectomy,reduce the traumatic responses,and facilitate postoperative recovery.