宣肺平喘汤加减结合穴位贴敷治疗咳嗽变异性哮喘风寒袭肺证的效果及对气道重塑的影响

Effect of modified Xuanfei Pingchuan decoction combined with acupoint application on cough variant asthma with wind-cold attacking lung syndrome and its influence on airway remodeling

目的探讨宣肺平喘汤加减结合穴位贴敷治疗咳嗽变异性哮喘风寒袭肺证的效果及对气道重塑的影响。方法选取2020年4月至2022年8月治疗的100例咳嗽变异性哮喘风寒袭肺证患者为研究对象,按照随机数字表法将其分为对照组与观察组,各50例。对照组接受常规西药治疗,观察组在对照组基础上加宣肺平喘汤加减结合穴位贴敷治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的嗜酸性粒细胞计数(EOS)、白细胞介素-4(IL-4)水平低于对照组,干扰素-γ(IFN-γ)水平高于对照组(P<0.05)。治疗后,观察组的呼出气一氧化氮(FeNO)、肺泡气一氧化氮(CaNO)低于对照组(P<0.05)。治疗后,观察组的结缔组织生长因子(CTGF)、人软骨糖蛋白-39(HC-gp39)、基质金属蛋白酶抑制因子-1(TIMP-1)及基质金属蛋白酶-9(MMP-9)水平低于对照组(P<0.05)。结论宣肺平喘汤加减结合穴位贴敷治疗咳嗽变异性哮喘风寒袭肺证的效果满意,可调节炎性因子指标,降低FeNO、CaNO,抑制气道重塑。

Objective To explore the effect of modified Xuanfei Pingchuan decoction combined with acupoint application on cough variant asthma with wind-cold attacking lung syndrome and its influence on airway remodeling.Methods A total of 100 patients with cough variant asthma with wind-cold attacking lung syndrome treated from April 2020 to August 2022 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 50 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with modified Xuanfei Pingchuan decoction combined with acupoint application on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the eosinophil counts(EOS)and interleukin-4(IL-4)level in the observation group were lower than those in the control group,and the level of interferon-γ(IFN-γ)was higher than that in the control group(P<0.05).After treatment,the fractional exhaled nitric oxide(FeNO)and alveolar nitric oxide(CaNO)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of connective tissue growth factor(CTGF),human cartilage glycoprotein-39(HC-gp39),tissue inhibitor of metalloproteinases-1(TIMP-1)and matrix metalloproteinase-9(MMP-9)in the observation group were lower than those in the control group(P<0.05).Conclusion Modified Xuanfei Pingchuan decoction combined with acupoint application in the treatment of cough variant asthma with wind-cold attacking lung syndrome has a satisfactory effect.It can regulate inflammatory factors indexes,reduce FeNO and CaNO,and inhibit airway remodeling.