达格列净、西格列汀联合个体化有氧运动治疗老年2型糖尿病合并轻度认知障碍的疗效观察

Effect of daggligin,sigliptin and individualized aerobic exercise on elderly T2DM with MCI

目的研究达格列净、西格列汀联合个体化有氧运动治疗老年2型糖尿病(T2DM)合并轻度认知障碍(MCI)的疗效。方法选取2022年6月-2023年6月天津市河西区挂甲寺街社区卫生服务中心诊疗的96例老年T2DM合并MCI患者为研究对象,以随机数字表法分为对照组与观察组,每组各48例。对照组仅使用西格列汀,观察组使用达格列净、西格列汀联合个体化有氧运动。比较两组患者血糖血脂、炎症与氧化应激、认知功能、情绪心理及生活质量指标。结果治疗后,对照组与观察组的FPG、2hPG、HbA1c、PPEG、MODD、TG、TC、HOMA-IR、CRP、IL-6、MDA水平与PAID-5、DMQLS评分低于治疗前,且观察组低于对照组(P<0.05),HOMA-β、SOD水平与MMSE、MoCA、WHO-5评分高于治疗前,且观察组高于对照组(P<0.05)。结论达格列净、西格列汀联合个体化有氧运动三联疗法可以通过改善T2DM合并MCI患者的血糖水平、血糖波动幅度、胰岛功能、血脂、炎症及氧化因子水平促进认知功能的提高,以减轻及延缓认知障碍,改善情绪及心理健康,提高生活质量。

Objective The paper explored effect of daggligin,sigliptin and individualized aerobic exercise on T2DM(type 2 diabctesmellitus)patients with MCI(mild cognitive impairment).Methods 96 elderly T2DM patients with MCI from June 2022 to June 2023 were randomly divided into control group and observation group,each group had 48 cases,blood glucose and lipid levels,inflammation and oxidative stress,cognitive function,emotional psychology,and life quality between groups were compared.Results Affer treatment,levels of FPG,2hPG,HbA1c,PPEG,MODD,TG,TC,HOMA-IR,CRP,IL-6,MDA and PAID-5,DMQLS in both groups decreased with observation group significantly lower than control group(P<0.05);levels of HOMA-β,SOD and MMSE,MoCA,WHO-5 scores increased with observation group significantly higher than control group(P<0.05).Conclusion For T2DM patients with MCI,daggligin and sitagliptin and individualized aerobic exercise can promote cognitive function by improving levels of blood glucose,blood glucose fluctuation amplitude,insulin,blood lipids,inflammation,and oxidative factor,which can alleviate cognitive impairment,improve emotional and mental health,and enhance life quality.