异基因造血干细胞移植后合并吉兰-巴雷综合征1例报告并文献复习

Guillain-Barre syndrome after allogeneic hematopoietic stem cell transplantation: a case report and literature review

异基因造血干细胞移植后合并吉兰-巴雷综合征较为罕见, 国内报道很少。吉兰-巴雷综合征发病急, 严重威胁患者生命, 需尽早诊断及治疗。1例急性髓系白血病患者行异基因造血干细胞移植后5个月余, 合并迟发急性肠道移植物抗宿主病后逐渐出现四肢肌无力、眼球运动受限, 经脑脊液、肌电图等检查, 明确诊断吉兰-巴雷综合征, 经大剂量静脉免疫球蛋白治疗, 肌力逐渐恢复, 预后良好。

Guillain-Barre syndrome rarely develops after allogeneic hematopoietic stem cell transplantation(allo-HSCT),and only a few reports exist in China.Guillain-Barre syndrome is an acute and life-threatening condition that requires early diagnosis and treatment.A patient with acute myeloid leukemia underwent allogeneic HSCT for>5 months and gradually developed limb muscle weakness and limited eye movement after coexisting with delayed acute intestinal graft-versus-host disease.After the examination of cerebrospinal fluid and electromyography,the diagnosis of Guillain–Barre syndrome was confirmed.After a high-dose intravenous immunoglobulin(IVIg)treatment,muscle strength gradually recovered,and the prognosis was good.