CA125、CA153表达与乳腺癌MRI IVIM-DWI参数的相关性及诊断价值研究

Study on Correlation of CA125 and CA153 Expressions and MRI IVIM-DWI Parameters in Patients with Breast Cancer and the Diagnostic Value

目的研究CA125、CA153表达与乳腺癌MRI IVIM-DWI参数的相关性及诊断价值。方法选择我院2021年5月至2023年5月收治的86例疑似乳腺癌患者,均行MRI IVIM-DWI扫描,采用化学发光免疫法检测其血清CA125、CA153水平。以病理检查结果作为“金标准”,将其分为良性组与恶性组,分析恶性组IVIM-DWI参数与血清CA125及CA153水平的相关性。绘制ROC曲线,分析IVIM-DWI参数、血清CA125及CA153水平在诊断乳腺癌中的价值。结果恶性组IVIM-DWI检查参数D与其血清CA125及CA153均呈负相关,D^(*)与CA125及CA153均呈正相关。ROC曲线显示,IVIM-DWI参数D在鉴别乳腺癌中的AUC最大(0.862),其次为血清CA153(0.753),D^(*)、f及CA125在鉴别乳腺癌中的AUC均低于0.70,鉴别效能较低。结论乳腺良性及恶性病变者IVIW-DWI参数、血清CA125及CA153水平均存在差异,各指标单独应用时,参数D以及血清CA153在鉴别乳腺恶性病变中的价值较高,可作为临床筛查乳腺癌的潜在指标。

Objective To study the correlation of CA125 and CA153 expressions and MRI IVIM-DWI parameters in patients with breast cancer and the diagnostic value.Methods 86 patients with suspected breast cancer admitted to our hospital from May 2021 to May 2023 were selected and given MRI IVIM-DWI.The serum CA125 and CA153 levels were detected by chemiluminescence immunoassay.Taking pathological results as the gold standard,they were divided into benign group and malignant group.The correlation of IVIM-DWI parameters with serum CA125 and CA153 levels in the malignant group was analyzed.ROC curves were drawn to analyze the value of IVIM-DWI parameters,serum CA125 and CA153 levels in the diagnosis of breast cancer.Results In the malignant group,MRI IVIM-DWI parameter D was negatively correlated with serum CA125 and CA153,and D*was positively correlated with CA125 and CA153.ROC curve showed that IVIM-DWI parameter D had the largest AUC(0.862),then serum CA153(0.753).D*,f and CA125 had an AUC below 0.70,with low differential efficacy.Conclusions IVIW-DWI parameters,and serum CA125 and CA153 levels are different between benign and malignant breast lesions;parameter D and serum CA153 are of higher value in identifying malignant breast lesions and can be potential indicators for clinical screening of breast cancer.