胃泌素-17联合幽门螺旋杆菌IgG抗体在萎缩性胃炎及早期胃癌诊断中的应用价值

Application Value of Gastrin-17 Combined with Helicobacter Pylori lgG Antibody in the Diagnosis of Atrophic Gastritis and Farly Gastric Cancer

目的探讨胃泌素-17(G-17)联合幽门螺旋杆菌IgG抗体(HP-IgG)在萎缩性胃炎(AG)及早期胃癌(GC)诊断中的应用价值。方法选取2020年1月至2023年3月我院收治的50例早期GC患者(早期GC组)及50例AG患者(AG组),另选取同期我院50例健康体检者(对照组),对比三组的血清G-17水平、HP-IgG阳性率,并对比早期GC组中HP-IgG阳性及HP-IgG阴性患者血清G-17水平,分析血清G-17联合HP-IgG对AG及早期GC的诊断效能。结果三组血清G-17水平、HP-IgG阳性率比较:早期GC组>AG组>对照组;早期GC组中HP-IgG阳性患者血清G-17水平高于HP-IgG阴性患者(P<0.05);绘制ROC曲线结果显示,血清G-17联合HP-IgG诊断AG、早期GC的AUC分别为0.749、0.803,均高于各指标单独诊断。结论AG患者、早期GC患者血清G-17及HP-IgG均呈现异常高表达,且两项指标联合检测对AG及早期GC均具有较高的诊断价值。

Objective To explore the application value of gastrin-17(G-17)combined with Helicobacter pylori IgG antibody(HP-IgG)in the diagnosis of atrophic gastritis(AG)and early gastric cancer(GC).Methods 50 patients with early GC(early GC group)and 50 patients with AG(AG group)admitted to our hospital from January 2020 to March 2023 were selected,and another 50 healthy subjects(control group)were selected.The serum G-17 levels and HP-IgG positive rates of the three groups were compared,and the serum G-17 levels of HP-IgG positive and HP-IgG negative patients in the early GC group were compared.The diagnostic efficacy of serum G-17 combined with HP-IgG for AG and early GC was analyzed.Results The comparison of serum G-17 level and HP-IgG positive rate among the three groups:early GC group>AG group>control group.In the early GC group,the serum G-17 level of HP-IgG positive patients was higher than that of HP-IgG negative patients(P<0.05).ROC curve results showed that the AUC of serum G-17 combined with HP-IgG in the diagnosis of AG and early GC was 0.749 and 0.803,respectively,which were higher than those of each index alone.Conclusions Serum G-17 and HP-IgG in patients with AG and early GC are abnormally high,and the combined detection of the two indicators for AG and early GC has high diagnosis value.