摘要
阿尔茨海默病(AD)是一种神经退行性疾病,主要表现为进行性记忆缺陷和认知功能下降。既往关于AD外周血生物标志物的研究多集中于病理标志物如β-淀粉样蛋白(Aβ)和磷酸化tau蛋白(p-tau)的改变上。本文围绕近几年AD外周血新型生物标志物如炎性因子、代谢指标、非编码RNA等的研究进展进行综述,以期为AD的诊断提供参考。
Alzheimer's disease(AD)is a neurodegenerative disease characterized by progressive memory deficits and cognitive decline.Previous studies of peripheral blood biomarkers in AD have been focused on alterations ofβ-amyloid(Aβ)and phosphorylated(p)-tau.This article reviews the research progress of new biomarkers,such as inflammatory factors,metabolic indicators,and non-coding RNA,in peripheral blood of AD in recent years,in order to provide references for AD diagnosis.
作者
张丹丹
任国强
吴晶
魏伟
李学忠
陈晓鹏
Zhang Dandan;Ren Guoqiang;Wu Jing;Wei Wei;Li Xuezhong;Chen Xiaopeng(Department of Neurology,Affiliated People's Hospital of Jiangsu University,Zhenjiang 212000,China;Department of Radiology,Affiliated People's Hospital of Jiangsu University,Zhenjiang 212000,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2024年第5期513-519,共7页
Chinese Journal of Neuromedicine
基金
江苏大学附属人民医院院级科研项目(Y2021018)。
