生酮饮食治疗结直肠癌的研究进展

Research progress of ketogenic diet in the treatment of colorectal cancer

结直肠癌是一种以高发病率和高死亡率为特征的肿瘤疾病,其发生和发展由基因、环境、生活方式等多方面因素共同决定。结直肠癌在发展过程中,肿瘤细胞的能量代谢发生异常改变导致癌细胞的葡萄糖摄取增加,葡萄糖供能成为肿瘤细胞主要的能量来源。生酮饮食是一种低碳水化合物的饮食模式,在此模式下,酮体成为机体细胞的主要能量来源,肿瘤细胞能量来源受到抑制,故生酮饮食被认为具有潜在的辅助抗肿瘤作用。该文将生酮饮食在结直肠肿瘤治疗方面的相关机制的研究结果进行综述分析,并探讨目前在治疗中应用生酮饮食所面临的主要问题。

Colorectal cancer is a tumor disease characterized by high morbidity and mortality.Its occurrence and development are determined by many factors,such as gene,environment,lifestyle and so on.During the development of colorectal cancer,abnormal changes in energy metabolism of tumor cells lead to increased glucose uptake of cancer cells,and glucose energy supply has become the main energy source of tumor cells.Ketogenic diet is a low-carbohydrate diet pattern,in which ketogenic body becomes the main energy source of body cells,and the energy source of tumor cells is inhibited,so ketogenic diet is considered to have potential auxiliary anti-tumor effects.In this paper,the mechanism of ketogenic diet in the treatment of colorectal cancer has been reviewed and analyzed,and the main problems in the application of ketogenic diet in the treatment of colorectal cancer were discussed.