超声影像参数与甲状腺乳头状癌患者淋巴结转移的相关性研究

Study on Correlation Between Ultrasound Image Parameters and Lymph Node Metastasis in Patients with Thyroid Papillary Carcinoma

目的:研究超声影像参数与甲状腺乳头状癌(PTC)患者淋巴结转移的相关性。方法:选取2019年6月—2022年6月信阳市人民医院收治的96例PTC患者为研究对象,根据术后病理检查将其分为颈部淋巴结转移组(n=31)和颈部淋巴未转移组(n=65)。所有患者在入组后均进行颈部超声检查,比较颈部淋巴结转移组与颈部淋巴结未转移组患者的超声影像学特征之间的差异,研究超声影像参数与PTC患者淋巴结转移的相关性。结果:单因素分析结果显示,两组患者的纵横比、结节数量、边缘、钙化、与被膜的关系、血流信号比较,差异有统计学意义(χ^(2)=5.112、14.971、4.873、32.612、16.361、48.061,P<0.05);logistics回归分析结果显示,纵横比(<2)、结节数量(多发)、边缘(不规则)、钙化(微小钙化)、与被膜关系(不连续)、血流信号(Ⅲ型)均是造成患者颈部淋巴结转移的危险因素,差异有统计学意义(OR=1.019、1.632、1.089、1.020、1.320、1.002,P<0.05);Spearman相关性分析结果显示,患者发生颈部淋巴结转移与纵横比(<2)、结节数量(多发)、边缘(不规则)、钙化(微小)、与被膜关系(不连续)、血流信号(Ⅲ型)呈现正相关,差异有统计学意义(r=0.651、0.402、0.744、0.506、0.683、0.443,P<0.05)。结论:超声影像参数与PTC患者淋巴结转移呈现显著的相关性,未来可作为术前诊断的重要参考。

Objective:To study the correlation between ultrasound image parameters and lymph node metastasis in patients with thyroid papillary carcinoma.Methods:96 patients with papillary thyroid carcinoma admitted to the hospital from June 2019 to June 2022 were selected as the study objects.According to the postoperative pathological examination results,they were divided into the cervical lymph node metastasis group(n=31)and the premetastatic group(n=65).After all patients were enrolled,the differences in ultrasonic imaging features between the cervical lymph node metastasis group and the premetastatic group were compared.And the correlation between ultrasonic image parameters and lymph node metastasis in patients with thyroid papillary carcinoma was studied.Results:There were statistically significant differences in the comparison of aspect ratio,nodule number,margin,calcification,relationship with capsule and blood flow signal between the two groups(χ^(2)=5.112,14.971,4.873,32.612,16.361,48.061;P<0.05).Logistics regression analysis showed that aspect ratio(<2),number of nodules(multiple),margin(irregular),calcification(micro),relationship with capsule(discontinuous),and blood flow(typeⅢ)were all risk factors for cervical lymph node metastasis,and the difference was statistically significant(OR=1.019,1.632,1.089,1.020,1.320,1.002;P<0.05).Spearman correlation analysis showed that the incidence of cervical lymph node metastasis in patients was positively correlated with aspect ratio(<2),number of nodules(multiple),margin(irregular),calcification(micro),relationship with capsule(discontinuous),and blood flow(typeⅢ)with statistically significant difference(r=0.651,0.402,0.744,0.506,0.683,0.443;P<0.05).Conclusion:Ultrasonographic parameters were significantly correlated with lymph node metastasis in patients with thyroid papillary carcinoma,which could be used as the important reference for preoperative diagnosis in the future.