干细胞治疗薄型子宫内膜的研究进展

Research progress on stem celll therapy for thin endometrium

子宫容受性的一个公认标志是子宫内膜的厚度,过薄的子宫内膜不仅会造成女性月经不规律,还会降低育龄期女性的胚胎着床率和活产率,也是导致辅助生殖周期取消的重要原因之一。目前有许多方法可用于治疗薄型子宫内膜,但尚未有明确的共识或指南。近些年来,干细胞因其具有无限自我更新和增殖分化为多种细胞类型的能力成为多学科研究的热点。利用干细胞修复受损的子宫内膜成为一种新的选择。移植经血、骨髓、脐带、胎盘及脂肪等不同来源的干细胞可以有效促进子宫内膜再生和恢复,改善子宫内膜的功能。本文对近年来干细胞治疗薄型子宫内膜的应用进展以及干细胞临床治疗的优缺点进行了分析,旨在为未来的临床治疗及科研创新提供思路。

The thickness of the endometrium is a widely-recognized indicator of uterine receptivity.An excessively thin endometrium not only leads to irregular menstruation in women but also decreases the embryo implantation rate and live birth rate among women of childbearing age.Moreover,it stands as a significant cause for the cancellation of assisted reproductive cycles.While numerous methods exist for treating thin endometrium,there are currently no definitive consensus or guideline.In recent years,stem cells have become the focus of multidisciplinary research due to their capacity for infinite self-renewal,proliferation and differentiation into diverse cell types.The utilization of stem cells to repair damaged endometrium has emerged as a new avenue.Transplanting stem cells from various sources,including menstrual blood,bone marrow,umbilical cord,placenta,and adipose tissue,has shown efficacy in promoting endometrial regeneration and recovery,thereby enhancing endometrial function.This paper provides an analysis of recent application progress of stem cell therapy for thin endometrium and the pros and cons of stem cell clinical treatment,aiming to offer insights for future clinical treatments and research innovations.