尿液错误折叠蛋白与子痫前期发病风险及不良妊娠结局的关系

Relationship between urinary misfolded proteins with risk of preeclampsia and adverse pregnancy outcomes

目的探讨尿液错误折叠蛋白与子痫前期发病风险及不良妊娠结局的关系。方法将2022年3月至2023年6月于该院进行产检的300例孕妇作为研究对象,通过刚果红斑点扩散法检测其尿液错误折叠蛋白水平。分析尿液错误折叠蛋白诊断子痫前期的灵敏度、特异度、阳性预测值和阴性预测值。根据孕妇子痫前期检出情况将其分为子痫前期组和非子痫前期组,比较2组孕妇一般资料、不良妊娠结局发生情况,分析尿液错误折叠蛋白与孕妇不良妊娠结局的关系。结果300例孕妇中有50例子痫前期孕妇,纳入子痫前期组,剩余250例非子痫前期孕妇纳入非子痫前期组;子痫前期组>29~34孕周的孕妇占比较高,为44.00%(22/50)。与非子痫前期组相比,子痫前期组不良妊娠结局发生率更高(P<0.05)。尿液错误折叠蛋白诊断子痫前期的阳性预测值为62.50%(40/64),阴性预测值为95.76%(226/236),检测灵敏度为80.00%(40/50),特异度为90.4%(226/250)。尿液错误折叠蛋白阳性孕妇不良妊娠结局发生率(20.31%)明显高于尿液错误折叠蛋白阴性孕妇(9.75%),差异有统计学意义(P<0.05)。结论尿液错误折叠蛋白与子痫前期发病风险及不良妊娠结局有关。

Objective To explore the relationship between urinary misfolded proteins with the risk of preeclampsia and adverse pregnancy outcomes.Methods A total of 300 pregnant women with prenatal examination in this hospital from March 2022 to June 2023 were included as the study subjects,and their urine misfolded protein was detected by using Congo red spot diffusion method.The sensitivity,specificity,positive predictive value and negative predictive value of urine misfolded protein for the diagnosis of preeclampsia were analyzed;they were divided into the preeclampsia group and non-preeclampsia group according to the preeclampsia detection situation in the pregnant women.The general data and occurrence situation of adverse reactions were compared between the two groups.The relationship between urine misfolded protein expression level with adverse reaction in the pregnant women was analyzed.Results Among 300 pregnant women,there were 50 case of preeclampsia(preeclampsia group),and the other 250 pregnant women were enroued in non-preeclampsia group;the proportion of the pregnant women of>29-34 pregnant weeks in the preeclampsia group was higher,accounting for 44.00%(22/50).The occurrence rate of adverse pregnant outcomes in the preeclampsia group was higher that that in the non-preeclampsia group(P<0.05).The positive predictive value and negative predictive value of urine misfolded protein for diagnosis of preeclampsia were 62.50%(40/64)and 95.76%(226/236),respectively,the sensitivity and specificity were 80.00%(40/50)and 90.4%(226/250),respectively.The incidence rate of adverse pregnant outcomes in the pregnant women with urine misfolded protein positive(20.31%)was significantly higher than that in the pregnant women with urine misfolded protein negative(9.75%),and the difference was statistically significant(P<0.05).Conclusion Urine misfolded protein is associated with the onset risk of preeclampsia and adverse pregnancy outcomes.