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健脾化痰方在肺癌患者化疗期间改善胃肠道不良反应及营养状况的临床研究

Clinical study on the application of Jianpi Huatan Formula in improving gastrointestinal adverse reactions and nutritional status in chemotherapy patients with lung cancer
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摘要 目的研究健脾化痰方在肺癌患者化疗期间改善胃肠道不良反应及营养状况的临床效果。方法将中国人民解放军东部战区总医院秦淮医疗区肿瘤内科2021年1月至2022年12月收治的86例肺癌化疗患者,按随机数字表法分为对照组及研究组,每组患者43例,对照组采用常规治疗干预,研究组在对照组基础上应用健脾化痰方。比较2组患者的中医症候评分、胃肠道不良反应发生情况、营养状况、癌因性疲乏状态及免疫功能。结果干预前2组患者各项中医证候评分、肿瘤患者主观整体营养状况评估量表(PG-SGA)评分、血清白蛋白(ALB)、血红蛋白(Hb)、免疫球蛋白G(IgG)、IgM、IgA,Piper疲乏修正量表(RPFS)评分比较差异均无统计学意义(P>0.05);干预后研究组患者各项中医证候评分、胃肠道不良反应发生率、RPFS评分均低于对照组,差异有统计学意义(P<0.05);干预后研究组PG-SGA评分低于对照组,ALB、Hb水平高于对照组,差异有统计学意义(P<0.05);干预后研究组患者IgG、IgM、IgA水平均高于对照组,差异有统计学意义(P<0.05)。结论在肺癌患者化疗期间应用健脾化痰方能够有效改善患者的临床症状、营养状况和癌因性疲乏状态,减少患者的胃肠道不良反应,提高患者的免疫功能,值得临床推广。 Objective To study the clinical effect of Jianpi Huatan Formula in improving gastrointestinal adverse reactions and nutritional status in chemotherapy patients with lung cancer.Methods Eighty-six chemotherapy patients with lung cancer admitted to Department of Oncology,Qinhuai Medical Area,General Hospital of Eastern Theater Command from January 2021 to December 2022 were randomly divided into a control group(n=43)and a study group(n=43).All patients received routine nursing intervention,those in the study group additionally received Jianpi Huatan Formula.The traditional Chinese medicine(TCM)symptom score,gastrointestinal adverse reactions,nutritional status,cancer-related fatigue,and immune function were compared between groups.Results Before intervention,there was no statistically significant difference in TCM syndrome scores,Patient-Generated Subjective Global Assessment(PG-SGA)scores,serum albumin(ALB),hemoglobin(Hb)levels,immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)levels,and Revised Piper Fatigue Scale(RPFS)scores between groups(P>0.05).After intervention,the TCM syndromes scores,incidence of gastrointestinal adverse reactions,and RPFS scores in the study group were significantly lower than those of the control group(P<0.05).After intervention,the PG-SGA score of the study group was significantly lower than that of the control group,while the levels of ALB and Hb were significantly higher(P<0.05).After intervention,the levels of IgG,IgM,and IgA in the study group were significantly higher than those of the control group(P<0.05).Conclusion The application of Jianpi Huatan Formula in chemotherapy patients with lung cancer can effectively improve their clinical symptoms,nutritional status,and cancer-related fatigue,reduce gastrointestinal adverse reactions,and improve their immune function,which is worthy of clinical promotion.
作者 崔王波 吴伟 余利 李惠玉 CUI Wangbo;WU Wei;YU Li;LI Huiyu(Department of Oncology,Qinhuai Medical Area,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002;Jurong City Houbai health center,Zhenjiang,Jiangsu 212400)
出处 《河北中医》 2024年第7期1074-1077,1082,共5页 Hebei Journal of Traditional Chinese Medicine
基金 国家自然科学基金资助项目(编号:82102547)。
关键词 健脾化痰方 肺癌 化疗 胃肠道不良反应 营养状况 Jianpi Huatan Formula Lung cancer Chemotherapy Gastrointestinal adverse reactions Nutritional status
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