D-二聚体/纤维蛋白原对血管性痴呆患者预后的评估价值

Prognostic Value of D-dimer/Fibrinogen in Patients with Vascular Dementia

目的分析D-二聚体/纤维蛋白原对血管性痴呆患者预后的评估价值。方法选择河南省职工医院2022年1月至2022年12月拟接受盐酸多奈哌齐片治疗的100例血管性痴呆患者作为研究对象。根据治疗效果分为有效组与无效组,比较两组患者的临床资料,使用Spearman相关性检验D-二聚体与纤维蛋白原之间的关系,使用点二列相关性检验D-二聚体/纤维蛋白原比值与血管性痴呆患者临床预后的关系,绘制受试者工作特征(ROC)曲线评估D-二聚体/纤维蛋白原比值对治疗效果的评估价值。结果治疗3个月后显效10例,有效43例,均纳入有效组,占比53.00%(53/100),另47例无效,纳入无效组,占比47.00%(47/100)。两组患者D-二聚体、纤维蛋白原、D-二聚体/纤维蛋白原、治疗后日常生活活动能力量表(ADL)评分、治疗后简易智力状态检查量表(MMSE)评分差异有统计学意义(P<0.05)。Spearman相关性检验显示,D-二聚体与纤维蛋白原水平呈正相关(r=0.477,P<0.001)。经点二列相关性检验显示,D-二聚体、纤维蛋白原以及D-二聚体/纤维蛋白原与治疗效果呈正相关(r>0,P<0.05);ROC曲线显示,D-二聚体、纤维蛋白原以及D-二聚体/纤维蛋白原对血管性痴呆患者预后具有良好的评估价值。结论D-二聚体/纤维蛋白原对血管性痴呆患者预后具有良好的评估价值。

Objective To analyze the prognostic value of D-dimer/fibrinogen in patients with vascular dementia.Methods A total of 100 patients with vascular dementia who were planned to be treated with donepezil hydrochloride tablets at Henan General Hospital from January 2022 to December 2022 were selected as the study subjects.According to the therapeutic effect,the patients were divided into effective group and ineffective group.The clinical data of the two groups were compared.Spearman correlation test was used to test the relationship between D-dimer and fibrinogen.The relationship between D-dimer/fibrinogen ratio and clinical prognosis of patients with vascular dementia was tested by point two column correlation.The receiver operating characteristic(ROC)curve was drawn to evaluate the value of D-dimer/fibrinogen ratio in evaluating the therapeutic effect.Results After 3 months of treatment,10 cases showed significant improvement and 43 cases were effective,they were included in the effective group,accounting for 53.00%(53/100).The other 47 cases were ineffective and included in the ineffective group,accounting for 47.00%(47/100).There was statistical difference between the two groups of patients in terms of D-dimer,fibrinogen,D-dimer/fibrinogen ratio,post treatment activities of daily living(ADL)score,and post treatment mini-mental state examination(MMSE)score(P<0.05).Spearman correlation test showed a positive correlation between D-dimer and fibrinogen(r=0.477,P<0.001).The point two column correlation test showed a positive correlation between D-dimer,fibrinogen,and D-dimer/fibrinogen ratio and treatment efficacy(r>0,P<0.05).The ROC curve showed that D-dimer,fibrinogen and D-dimer/fibrinogen had good evaluation value for the prognosis of patients with vascular dementia,and the AUC was 0.878,0.879 and 0.899,respectively.Conclusion D-dimer/fibrinogen has a good evaluation value for the prognosis of patients with vascular dementia.