间歇性禁食对纠正非酒精性脂肪肝患者血脂、肝功能及体重的效果

Effect of Intermittent Fasting on Correction of Blood Lipids,Liver Function and Body Weight in Patients with Non-alcoholic Fatty Liver Disease

目的探讨间歇性禁食对纠正非酒精性脂肪肝患者的临床应用效果。方法选择经新乡医学院第一附属医院消化科门诊及体检确定为非酒精性脂肪肝的160例患者为研究对象,采用随机分组的方法分为两组,观察组采用间歇性禁食方法12周,对照组正常进食。12周后比较干预前后患者血脂、肝功能及体重情况,并观察不良反应。结果干预前,对照组与观察组患者血脂、肝功能及体重等比较,差异无统计学意义(P>0.05)。干预后,观察组患者甘油三酯、总胆固醇、谷丙转氨酶、谷草转氨酶、总胆红素、体重、体重指数优于对照组(P<0.05)。观察组有7例出现了心慌。结论间歇性禁食对纠正非酒精性脂肪肝患者的血脂、肝功能及体重有明显的疗效,且无明显不良反应,值得进一步临床推广应用。

Objective To investigate the clinical effect of intermittent fasting on correcting nonalcoholic fatty liver disease.Methods A total of 160 patients who were diagnosed as non-alcoholic fatty liver disease through physical examination by the gastroenterology department of the First Affiliated Hospital of Xinxiang Medical University were selected as the research subjects.They were randomly divided into two groups.The observation group used intermittent fasting method,and completed 12 weeks of experiment,while the control group ate normally.The blood lipid,liver function,and body weight of patients before and after intervention were compared after 12 weeks,and adverse effects were observed.Results Before the intervention,there were no differences in blood lipid,liver function and body weight between the control group and the observation group(P>0.05).After the intervention,patients in the observation group had better triglycerides,total cholesterol,glutamic-pyruvic transaminase,glutamic-oxalacetic transaminase,total bilirubin,body weight and body weight index than those in the control group(P<0.05).Seven patients in the observation group experienced palpitation.Conclusion Intermittent fasting has obvious efficacy in correcting blood lipids,liver function and body weight in patients with non-alcoholic fatty liver disease,and there are no obvious adverse reactions,which is worthy of further clinical promotion and application.