肺癌患者血清CA724、CA153、SCC水平与病理特征及术后复发转移的关系

Relationship Between Serum CA724,CA153,SCC and Pathological Characteristics,Postoperative Recurrence and Metastasis in Patients with Lung Cancer

目的探讨肺癌(LC)患者血清糖类抗原724(CA724)、糖类抗原153(CA153)、鳞癌抗原(SCC)水平与病理特征及术后复发转移的关系。方法选取2019年6月至2020年12月在周口市中心医院接受手术治疗的102例LC患者,根据其2 a后是否存在复发转移分为复发转移组和未复发转移组,比较两组术前血清CA724、CA153和SCC水平及病理特征,分析影响术后复发转移的因素。结果随访后,102例患者中有65例发生复发转移,发生率为63.73%;复发转移组CA724、CA153和SCC水平均高于未复发转移组(P<0.05);腺癌组CA724水平高于小细胞肺癌组和鳞癌组(P<0.05),3组CA153水平差异无统计学意义(P>0.05);鳞癌组SCC水平高于小细胞肺癌组和腺癌组(P<0.05)。Ⅱ期和Ⅲ期CA724、CA153和SCC水平高于Ⅰ期(P<0.05)。复发转移组和未复发转移组TNM分期和分化程度差异有统计学意义(P<0.05)。Cox单因素回归分析结果显示,TNM分期、高水平CA724、CA153、SCC和分化程度是LC患者术后复发转移的影响因素(P<0.05);多因素回归分析结果显示,TNM分期为Ⅲ期和高水平的CA724、CA153和SCC均为影响LC患者术后复发转移的独立危险因素(P<0.05)。结论LC患者血清CA724、CA153、SCC表达水平与LC病理特征和术后复发转移关系密切,临床可通过检测血清CA724、CA153、SCC水平来评估术后复发转移情况。

Objective To explore the relationship between serum carbohydrate antigen 724(CA724),carbohydrate antigen 153(CA153),squamous cell carcinoma antigen(SCC)and pathological characteristics,postoperative recurrence and metastasis in patients with lung cancer(LC).Methods A total of 102 patients with LC undergoing surgical treatment in Zhoukou Central Hospital were enrolled from June 2019 to December 2020.According to presence or absence of recurrence and metastasis at 2 years after surgery,they were divided into recurrence-metastasis group and non-recurrence-metastasis group,the levels of serum CA724,CA153 and SCC,and pathological characteristics in the two groups were compared.The influencing factors of postoperative recurrence and metastasis were analyzed.Results After follow-up,65 out of 102 patients experienced recurrence and metastasis,accounting for 63.73%.The levels of CA724,CA153 and SCC in recurrence-metastasis group were higher than those in non-recurrence-metastasis group(P<0.05).CA724 level in adenocarcinoma group was higher than those in small cell lung cancer group and squamous cell carcinoma group(P<0.05),but there was no statistical difference in CA153 level among the three groups(P>0.05).SCC level in squamous cell carcinoma group was higher than those in small cell lung cancer group and adenocarcinoma group(P<0.05).The levels of CA724,CA153 and SCC in patients at stages Ⅱ and Ⅲ were higher than those at stage Ⅰ(P<0.05).There were statistical differences in TNM staging and differentiation degree between recurrence-metastasis group and non-recurrence-metastasis group(P<0.05).The results of Cox univariate regression analysis showed that TNM staging,high levels of CA724,CA153 and SCC,and differentiation degree were influencing factors of postoperative recurrence and metastasis in LC patients(P<0.05).The results of multivariate regression analysis showed that TNM staging at stage Ⅲ,and high levels of CA724,CA153 and SCC were independent risk factors of postoperative recurrence and metastasis.Conclusion The expression levels of serum CA724,CA153 and SCC are closely related to pathological characteristics and postoperative recurrence and metastasis in LC patients.Clinically,levels of serum CA724,CA153 and SCC can be applied to evaluate postoperative recurrence and metastasis.