术前血清白细胞介素-10表达对子宫内膜异位症患者术后复发的预测价值

Predictive Value of Preoperative Serum Interleukin-10 Expression on Postoperative Recurrence in Patients with Endometriosis

目的分析术前血清白细胞介素-10(IL-10)表达对子宫内膜异位症(EMT)患者术后复发的预测价值。方法选取2019年1月至2021年5月于商丘市立医院接受腹腔镜保守性手术治疗并随访至2023年5月的124例EMT患者作为研究对象。于术前检测患者血清IL-10表达,并根据术后复发情况分为复发组和未复发组。比较两组血清IL-10表达和一般临床资料。采用logistic回归模型分析EMT患者术后复发的危险因素,并绘制受试者工作特征(ROC)曲线分析血清IL-10表达对EMT患者术后复发的预测价值。结果124例患者完成试验,其中26例患者术后复发,复发率为20.97%。不同术后复发情况的EMT患者的美国生育协会标准(r-AFS)分期、痛经程度、血清糖类抗原125(CA125)和血清IL-10表达比较,差异有统计学意义(P<0.05)。经logistic回归模型结果显示r-AFS分期高、痛经程度高、血清CA125和IL-10表达升高是EMT患者术后复发的独立危险因素(P<0.05)。绘制ROC曲线,结果显示血清CA125、IL-10、r-AFS分期、痛经程度单独及血清CA125、IL-10二者联合、以及四者联合预测EMT患者术后复发的曲线下面积(AUC)分别为0.701、0.757、0.641、0.642、0.860、0.860;血清IL-10单独预测与二者联合、四者联合的预测价值相近(Z=1.297、1.297,P=0.195、0.195)。结论血清IL-10表达与EMT患者术后复发具有相关性,且对术后复发具有预测价值,与血清CA125联合预测价值更高,可作为预测患者术后复发的辅助指标。

Objective To explore the predictive value of preoperative serum interleukin-10(IL-10)expression for postoperative recurrence of endometriosis(EMT).Methods A total of 124 EMT patients who underwent laparoscopic conservative surgery in Shangqiu Municipal Hospital from January 2019 to May 2021 and were followed up until May 2023 were selected as the study subjects.The expression of serum IL-10 was detected before operation,and the patients were divided into recurrence group and non-recurrence group according to the postoperative recurrence.Serum IL-10 expression and general clinical data were compared between the two groups.Logistic regression model was used to analyze the risk factors for postoperative recurrence in EMT patients,and a receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum IL-10 expression for postoperative recurrence in EMT patients.Results A total 124 patients completed the trial,among them,26 patients experienced postoperative recurrence,with a recurrence rate of 20.97%.There were statistical significant differences in the American Fertility Association(r-AFS)staging,degree of dysmenorrhea,serum carbohydrate antigen 125(CA125),and serum IL-10 expression among EMT patients with different postoperative recurrence rates(P<0.05).The logistic regression model results showed that high r-AFS staging,high degree of dysmenorrhea,and elevated serum CA125 and IL-10 expression were independent risk factors for postoperative recurrence in EMT patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum CA125,IL-10,r-AFS stage,dysmenorrhea degree alone,serum CA125 and IL-10 combined,and serum CA125 and IL-10 combined in predicting postoperative recurrence of EMT patients were 0.701,0.757,0.641,0.642,0.860 and 0.860,respectively.The predictive value of serum IL-10 alone was similar to that of the combination of the two and the combination of the four(Z=1.297,1.297,P=0.195,0.195).Conclusion The expression of serum IL-10 is correlated with postoperative recurrence in EMT patients,and has predictive value for postoperative recurrence.Combined with serum CA125 has higher predictive value and can be used as an auxiliary indicator for predicting postoperative recurrence in patients.