肝硬化患者肌少症的管理研究进展

Research Progress in the Management of Sarcopenia in Patients with Liver Cirrhosis

肝硬化常常导致机体能量代谢、激素分泌和免疫稳态发生异常,这些代谢过程的紊乱会导致肌少症或病理性肌肉萎缩。肌少症是肝硬化患者常见并发症之一,常常预示患者预后不佳,包括住院时间、感染性并发症和死亡率等。准确评估、早期营养支持和及时治疗对于肝硬化并肌少症患者具有重要意义。本文综述了肝硬化患者肌少症的发生机制、肌少症评估工具和干预措施。

Cirrhosis predisposes to abnormalities in energy,hormonal,and immunological homeostasis.Disturbances in these metabolic processes create susceptibility to sarcopenia or pathological muscle wasting.Sarcopenia is prevalent in cirrhosis.Its presence portends significant adverse outcomes including the length of hospital stay,infectious complications,and mortality.This highlights the importance of identification of at-risk individuals with early nutritional,therapeutic and physical therapy intervention.This manuscript summarizes literature relevant to sarcopenia in cirrhosis,describes mechanism,evaluation methods and intervention measures for sarcopenia.