丹红注射液联合静脉溶栓治疗缺血性脑卒中疗效研究

Efficacy of Danhong Injection combined with intravenous thrombolysis in treatment of ischemic stroke

目的观察丹红注射液联合静脉溶栓治疗缺血性脑卒中的疗效。方法将我院121例缺血性脑卒中患者随机分为对照组60例与治疗组61例。对照组行静脉溶栓治疗,治疗组行丹红注射液联合静脉溶栓治疗。观察比较两组总有效率、颈动脉斑块面积、斑块厚度、内膜中层厚度、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血液流变学指标、日常生活能力(ADL)、美国国立卫生研究所脑卒中(NIHSS)评分、不良反应。结果治疗后,治疗组总有效率高于对照组(P<0.05);两组颈动脉斑块面积和厚度、内膜中层厚度、TC、TG、LDL-C水平、全血高切和低切黏度、血小板聚集率、红细胞压积、NIHSS评分均低于治疗前,治疗组上述指标低于对照组(P<0.05);两组ADL评分高于治疗前,治疗组ADL评分高于对照组(P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论丹红注射液联合静脉溶栓治疗缺血性脑卒中效果显著,改善神经功能缺损,减少颈动脉斑块,降低血脂,调节血液流变性,安全性高。

Objective To observe the efficacy of Danhong Injection combined with intravenous thrombolysis in treatment of ischemic stroke.Methods 121 cases of ischemic stroke patients were randomly divided into control group(60 cases)and treatment group(61 cases).Control group was treated with intravenous thrombolysis,and treatment group was treated with Danhong Injection on the basis of control group.The total effective rate,carotid artery plaque area,plaque area,intimart-media thickness,blood lipids(total cholesterol TC,triglyceride TG,low-density lipoprotein cholesterol LDL-C),blood rheological indexes,ability of daily living(ADL),National Institutes of Health Stroke Scale(NIHSS)score,and adverse reactions were observed.Results After treatment,the total effective rate of treatment group was higher than that of control group(P<0.05),and the area and thickness of carotid artery plaque,intima-media thickness,TC,TG,LDL-C levels,high-cut and low-cut viscosity of whole blood,platelet aggregation rate,hematocrit and NIHSS score in treatment group were lower than those before treatment,and were lower than control group(P<0.05);the ADL score of both groups was higher than before treatment,and was higher in treatment group than control group(P<0.05);there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Danhong Injection combined with intravenous thrombolysis has a significant effect in treatment of ischemic stroke,improving neurological deficits,reducing carotid plaque,reducing blood lipids,and regulating blood rheology with high safety.