柴胡桂枝干姜汤加减联合普拉克索治疗中风后不宁腿综合征临床研究

Clinical observation on modified Chaihu Guizhi Ganjiang Decoction combined with pramipexole in treatment of restless leg syndrome after stroke

目的观察柴胡桂枝干姜汤加减联合普拉克索治疗中风后不宁腿综合征(RLS)的临床疗效。方法将我院60例中风后RLS患者随机分为联合组与对照组各30例,对照组服用普拉克索,联合组服用柴胡桂枝干姜汤加减联合普拉克索。比较两组总有效率,比较国际RLS严重程度量表(IRLS)、匹兹堡睡眠质量指数(PSQI)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,测定C反应蛋白(CRP)、白细胞介素-6(IL-6)含量,统计治愈时间、1个月复发率。结果治疗后,联合组总有效率高于对照组(P<0.05);两组IRIS、PSQI、HAMA、HAMD评分均显著低于治疗前(P<0.05),联合组上述指标评分均显著低于对照组(P<0.05);两组CRP、IL-6水平均显著低于治疗前(P<0.05),联合组CRP、IL-6水平均显著低于对照组(P<0.05);联合组治愈时间、复发率显著低于对照组(P<0.05)。结论柴胡桂枝干姜汤加减联合普拉克索治疗中风后RLS的临床疗效显著,可降低病情严重程度,改善睡眠质量,缓解焦虑和抑郁情绪,下调炎症因子,复发率低。

Objective To observe the clinical efficacy of modified Chaihu Guizhi Ganjiang Decoction combined with pramipexole in treatment of post-stroke restless leg syndrome(RLS).Methods 60 patients with post-stroke RLS were randomly divided into combination group and control group,with 30 cases in each group.Control group received pramipexole,while combination group received modified Chaihu Guizhi Ganjiang Decoction on the basis of control group.The total effective rates,the International RLS Severity Scale(IRLS),Pittsburgh Sleep Quality Index(PSQI),Hamilton Anxiety Scale(HAMA),and Hamilton Depression Scale(HAMD)scores,C-reactive protein(CRP)and interleukin-6(IL-6)levels,healing time,and the1-month recurrence rate of the two groups were compared.Results The total effective rate of combination group was higher than that of control group(P<0.05);the IRIS,PSQI,HAMA and HAMD scores of both groups were significantly lower than before treatment(P<0.05),and were significantly lower in combination group than control group(P<0.05);the average levels of CRP and IL-6 in both groups were significantly lower than before treatment(P<0.05),and were significantly lower in combination group than control group(P<0.05);the healing time was significantly shorter,and recurrence rate was significantly lower in combination group than those in control group(P<0.05).Conclusion The clinical efficacy of modified Chaihu Guizhi Ganjiang Decoction combined with pramipexole in treatment of RLS after stroke is significant.It reduces the severity of the condition,improves sleep quality,relieves anxiety and depression,downregulates inflammatory factors,and has a low recurrence rate.