胃复春结合四联疗法治疗幽门螺旋杆菌相关性胃溃疡临床疗效观察及对胃肠激素的影响

Clinical Observation of Weifuchun(胃复春)Combined with Quadruple Therapy in Treatment of Helicobacter pylori Associated Gastric Ulcer and Its Influence on Gastrointestinal Hormone Indexes

目的探讨四联疗法结合胃复春在幽门螺旋杆菌相关性胃溃疡治疗中的效果观察及对胃肠激素相关指标的影响。方法选取浙医健衢州医院2019年2月—2022年2月期间收治的105例幽门螺旋杆菌相关性胃溃疡患者,按随机数字表法分为对照组(52例)与治疗组(53例)。对照组采取四联疗法治疗,治疗组在对照组基础上联合胃复春辅助治疗。对比两组治疗后各症状消失时间,治疗前后炎症因子、胃肠激素指标变化水平,记录其疗效和不良反应情况。结果与对照组相比,治疗组总有效率更高(96.23%vs 82.69%)(χ^(2)=5.126,P=0.024);相比对照组,治疗组治疗后腹胀、腹痛、便血、嗳气的消失时长更短(P<0.05);两组治疗前炎症反应因子水平对比无明显差异(P>0.05),治疗后两组干扰素-γ(INF-γ)、白细胞介素-2(IL-2)、IL-12水平均降低,且相比对照组,治疗组治疗后INF-γ、IL-2、IL-12水平更低(P<0.05);两组治疗前炎胃肠激素指标水平对比无明显差异(P>0.05),治疗后两组胃泌素(GAS)、胃动素(MTL)水平降低、生长抑素(SS)水平升高,且相比对照组,治疗组治疗后GAS、MTL水平更低,SS水平更高(P<0.05);相比对照组,治疗组不良反应发生率更低(3.77%vs 19.23%)(χ^(2)=6.195,P=0.013)。结论针对幽门螺旋杆菌相关性胃溃疡患者采取胃复春辅助四联疗法治疗可提高疗效,缩短症状改善时间,抑制炎症因子分泌,改善患者胃肠激素水平,不良反应少,更具安全性。

Objective To investigate the clinical efficacy of quadruple therapy combined with Weifuchun(胃复春)in the treatment of Helicobacter pylori associated gastric ulcer and its influence on gastrointestinal hormone indexes.Methods A total of 105 patients with Helicobacter pylori associated gastric ulcer were divided into control group and treatment group according to random number table method.The control group(52 cases)was treated with quadruple therapy.The treatment group(53 cases)was combined with Weifuchun.The time of symptom disappearance,the changes of inflammatory factors and gastrointestinal hormone indexes before and after treatment were compared between the two groups,and the efficacy and adverse reactions were recorded.Results Compared with that of the control group,the total effective rate of the treatment group was higher(96.23%vs 82.69%)(χ^(2)=5.126,P=0.024).Compared with the control group,the patients in the treatment group had shorter disappearance time of abdominal pain,abdominal distension,belching and blood in stool after treatment(P<0.05).There was no significant difference in the levels of inflammatory response factors between the two groups before treatment(P>0.05),and the levels of interferon-γ(INF-γ),interleukin-2(IL-2)and interleukin-12(IL-12)in the two groups after treatment were decreased,and compared with those of the control group,the levels of INF-γ,IL-2 and IL-12 of the treatment group after treatment were lower(P<0.05).There was no significant difference between the two groups in the levels of gastrointestinal hormones before treatment(P>0.05).After treatment,the levels of gastrin(GAS)and motilin(MTL)decreased and the levels of somatostatin(SS)increased in the two groups,and compared with those of the control group,the levels of GAS and MTL were lower and the levels of SS were higher in the treatment group after treatment(P<0.05).Compared with that in the control group,the incidence of adverse reactions in the treatment group was lower(3.77%vs 19.23%)(χ^(2)=6.195,P=0.013).Conclusion For the patients with Helicobacter pylori associated gastric ulcer,the treatment of Weifuchun combined with quadruple therapy can improve the curative effect,shorten the time of symptom improvement,inhibit the secretion of inflammatory factors and improve the levels of gastrointestinal hormones in patients with fewer adverse reactions,and it is more safe.