复方异丙托溴铵溶液联合布地奈德混悬液雾化吸入治疗急诊哮喘患儿的临床效果

Clinical Effects of the Combined Use of Kebite and Pumiconazole Nebulized Inhalation in the Treatment of Emergency Asthma in Children

目的观察急诊哮喘患儿采取复方异丙托溴铵溶液联合布地奈德混悬液雾化吸入治疗的临床价值。方法选取2021年12月至2023年12月本院收治的200例急诊哮喘患儿资料进行回顾性研究。根据不同的治疗方式对患者进行分组工作,包括对照组(100例,布地奈德混悬液)、观察组(100例,复方异丙托溴铵溶液联合布地奈德混悬液)。对比两组治疗效果。结果观察组啰音、咳嗽、哮鸣、气喘等症状消失时间均短于对照组(均P<0.05);治疗后,观察组用力肺活量、第一秒用力呼气容积、呼气流量峰值以及血氧分压水平均高于对照组(均P<0.05);治疗后,观察组氧饱和水平对比对照组无差异(P>0.05);观察组动脉血二氧化碳分压水平、FeNO水平、并发症发生率以及疾病复发率均低于对照组(均P<0.05)。结论在急诊哮喘患儿中,通过应用复方异丙托溴铵溶液联合布地奈德混悬液联合治疗,能够有效改善症状,调节患者肺功能、血气指标,有利于降低并发症发生率、疾病复发率。

Objective Observe the clinical value of aerosol inhalation treatment of inhalation compound ipratropium bromide solution and inhalation suspension in children with emergency asthma.Methods The data of 200 children with emergency asthma admitted to our hospital from December 2021 to December 2023 were selected for retrospective study.The patients were grouped to work according to different treatment modalities,including the control group(100 cases,budesonide suspension),observation group(100 cases,compound ipratropium bromide solution combined with budesonide suspension).Compare the effects of treatment in the two groups.Results The disappearance time of symptoms such as rales,cough,croup and shortness of breath in the observation group was shorter than that in the control group(all P<0.05);after treatment,the exertion lung volume,first second exertion expiratory volume,peak expiratory flow rate,and partial pressure of blood oxygen in the observation group were higher than that in the control group(all P<0.05);there was no difference in the level of oxygen saturation in the observation group compared with that of the control group(all P>0.05);the level of arterial carbon dioxide partial pressure,FeNO level,complication rate and disease recurrence rate of the observation group were all lower than that of the control group(all P<0.05).Conclusions In children with emergency asthma,the combination treatment of compound ipratropium bromide solution and budesonide suspension for inhalation can effectively improve the symptoms of the patients,regulate the lung function and blood gas indexes of the patients,which is conducive to reduce the complication rate,disease recurrence rate.