辅助生殖技术子代神经心理发育相关因素探究

Study on factors related to neuropsychological development of assisted reproductive technology

目的探究辅助生殖技术对子代神经心理发育的影响因素。方法选取2019年12月至2022年6月于郑州大学第三附属医院儿童保健科进行健康检查的辅助生殖技术和自然受孕的婴幼儿共241例,辅助生殖技术组196例作为研究组,同期自然受孕子代45例作为对照组,均采用GESELL评估其神经心理发育水平。结果辅助生殖组和自然受孕组儿童在分娩方式、出生性别、早产发生率方面,差异无统计学意义(P>0.05);在适应性、大运动、精细运动、语言及个人-社会五个能区其发育商方面,差异无统计学意义(P>0.05);鲜胚移植和冻胚移植其子代在适应性、大运动、精细运动、语言及个人-社会五个能区其发育商方面,差异无统计学意义(P>0.05);辅助生殖组其母亲年龄与儿童的语言发育呈负相关;出生体重与适应性、大运动、精细运动、语言及个人-社会五个能区均呈负相关。结论不同移植方式的辅助生殖技术对子代的神经心理发育无明显不良影响,低出生体重、高龄妊娠夫妻的子代其神经心理发育水平较差。

Objective To explore the influence factors assisted of reproductive technology on the neuropsychological development of offspring.Methods A total of 241 infants who underwent assisted reproductive technology and natural conception for health examination in the Child Health Care Department of the third Affiliated Hospital of Zhengzhou University from December 2019 to June 2022 were selected.196 children born through assisted reproductive technology as the study group,and 45 natural pregnancy children as the comparison group,and their neuropsychological development level was assessed by GESELL.Results There were no significant differences between the assisted reproduction group and the natural pregnancy group in delivery mode,birth sex,and preterm birth rate(P>0.05).The development quotient in adaptability,big movement,fine movement,language and individual-society have no significant differences between two groups(P>0.05).Additionally,it resulted in no significant difference in the development quotient of the offspring for fresh embryo transfer and frozen embryo transfer in the five functional areas of adaptability,big movement,fine movement,language and individual-society;in the assisted reproduction group,the age of mother was negatively correlated with the language development of children;the birth weight was negatively correlated with adaptability,big movement,fine movement,language and individual-society.Conclusion Assisted reproductive technology with different transplantation methods had no obvious adverse effects on the neuropsychological development offspring.children of light birth weight,elder pregnant couples had poor neuropsychological development.