痰热浓煎剂联合西药治疗儿童肺炎支原体肺炎临床观察

Clinical Observation of Tanrenong Decoction in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children

目的探讨痰热浓煎剂联合西药治疗儿童肺炎支原体肺炎临床疗效。方法选择于南京市中西医结合医院住院的肺炎支原体肺炎患儿82例,根据随机数字表法分为观察组与对照组,对照组患儿给予雾化、抗炎、平喘治疗,观察组患儿给予痰热浓煎剂治疗。观察两组患儿治疗前后中医证候评分、症状体征消失时间(发热、咳嗽、肺部啰音)、炎症指标(C反应蛋白、红细胞沉降率、白细胞介素-6)、肺功能指标(用力肺活量、呼气峰值流速、最大呼气中期流速)及不良反应情况。结果治疗后观察组总有效率95.12%,对照组总有效率为80.49%,观察组高于对照组(P<0.05);观察组发热消失时间、咳嗽消失时间、肺部啰音消失时间均快于对照组(P<0.05);治疗后两组中医证候评分、血清C反应蛋白、红细胞沉降率、白细胞介素-6水平均较治疗前降低,且观察组低于对照组(P<0.05);治疗后两组用力肺活量、呼气峰值流速、最大呼气中期流速均较治疗前升高,且观察组高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论痰热浓煎剂联合西药治疗儿童肺炎支原体肺炎临床疗效显著。

Objective:To investigate the clinical efficacy of Tanrenong Decoction in the treatment of mycoplas⁃ma pneumonia in children.Methods:A total of 82 children with mycoplasma pneumoniae pneumonia hospitalized in Nanjing Hospital of Integrated Traditional Chinese and Western Medicine were selected and divided into the control group and observation group according to random number table method.The control group was treated with atomization,anti-inflammatory,anti-asthmatic treatment,while the observation group was added with Tanrenong Decoction.The clinical efficacy,TCM pattern scores,disappearance time of symptoms and signs(fever,cough,lung rales),inflammatory indexes(C-reactive protein,erythrocyte sedimentation rate,interleukin-6),lung function in⁃dexes(forced vital capacity,peak expiratory flow rate,maximum mid-expiratory flow rate)and adverse reactions were observed.Results:After treatment,the total effective rate of the observation group was 95.12%,which was higher than 80.49%of the control group(P<0.05),and the time of disappearance of fever,cough and pulmonary rales in the observation group was faster than that of the control group(P<0.05).After treatment,the TCM syndrome score,serum C-reactive protein,erythrocyte sedimentation rate and interleukin-6 levels in the two groups were lower than those before treatment,and the observation group were lower than those in the control group(P<0.05).After treatment,the forced vital capacity,peak expiratory flow rate and mid-maximum expiratory flow rate of the two groups were higher than those before treatment,and the observation group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical efficacy of Tanrenong Decoction combined with western medicine in the treatment of mycoplasma pneumoniae in children is significant.