从化瘀法探讨加味桂枝茯苓丸对糖尿病及并发症的影响

To Explore the Effect of Jiawei Guizhi Fuling Pill on Diabetes Mellitus from the Method of Removing Stasis

糖尿病(diabetes mellitus,DM)发病率高且增长速度快,严重危害患者生命和影响患者的生活质量。西医治疗DM多选择抗炎、抗氧化、改善微循环等药物,但药物靶点比较单一且毒副作用大,限制了其在DM治疗中的使用。中医认为瘀血阻络是DM发生的主要机制,桂枝茯苓丸是活血化瘀的代表方剂,加味桂枝茯苓丸是在桂枝茯苓丸的基础上,加入牛膝、黄芪、生姜、大枣等中药,能够有效降低DM及其并发症的发生率。文章通过从化瘀法探讨加味桂枝茯苓丸治疗DM及其并发症的作用机理,为中医药防治DM提供新的临床经验和理论依据。

Diabetes mellitus(DM)has a high incidence rate and a rapid growth rate,which seriously endangers the life of patients and affects their quality of life.Western medicine often chooses anti-inflammatory,antioxidant,and micro-circulation improving drugs to treat DM,but the drug targets are relatively single and have large toxic and side effects,which limits its use in DM treatment.Traditional Chinese medicine believes that blood stasis and obstruction of collaterals are the main mechanism of DM. Guizhi Fuling Pill is a representative prescription for promoting bloodcirculation and removing blood stasis. Jiawei Guizhi Fuling Pill is based on Guizhi Fuling Pill, and adds Chinese medicinessuch as Achyranthes bidentata, Astragalus, ginger, and jujube, which can effectively reduce the incidence of DMand its complications. This article explores the mechanism of action of Jiawei Guizhi Fuling Pill in the treatment of DMand its complications from the perspective of removing blood stasis, and provides new clinical experience and theoreticalbasis for the prevention and treatment of DM with traditional Chinese medicine.