参蛭和胃方对气阴两虚夹瘀型糖尿病胃轻瘫患者的临床观察

Clinical Observation on Shenzhi Hewei Decoction for Diabetic Gastroparesis of Qi-Yin Deficiency and Stasis Type

目的:观察参蛭和胃方对气阴两虚夹瘀型糖尿病胃轻瘫(Diabetic Gastr oparesis,DGP)患者的临床疗效。方法:选取2021年10月1日—2023年9月30日亳州市华佗中医院住院治疗的84例气阴两虚夹瘀型DGP患者作为研究对象,42例对照组患者在常规西药降糖治疗基础上予以口服多潘立酮片及生活方式配合等综合治疗,42例治疗组患者在对照组治疗的基础上予以参蛭和胃方口服治疗。观察治疗前后两组患者的总疗效、中医证候症状积分量表、匹兹堡睡眠质量指数量表、焦虑自评量表、抑郁自评量表、胃泌素-17、胃排空时间、空腹血糖、餐后2h血糖、糖基化血红蛋白,对两组疗效指标对比分析。结果:治疗组总有效率为97.6%(41/42),显著优于对照组的83.3%(35/42),P<0.05。治疗后治疗组的中医证候症状评分、匹兹堡睡眠质量指数量表、焦虑自评量表、抑郁自评量表、胃泌素-17、胃排空时间、空腹血糖、餐后2h血糖、糖基化血红蛋白均低于治疗前且低于治疗后对照组,P<0.05。结论:参蛭和胃方对气阴两虚夹瘀型DGP患者临床疗效确切,可有效改善DGP患者胃肠道相关不适症状,改善患者睡眠质量,降低焦虑抑郁发生风险,并可有效调节患者胃肠激素及胃排空时间,值得临床应用推广。

Objective:To observe the clinical efficacy of Shenzhi Hewei recipe on patients with diabetic gastroparesis(DGP)of Qi and yin deficiency and stasis type.Methods:A total of 84 patients with Qi and yin deficiency and stasis type DGP who were hospitalized in Bozhou Huatuo Hospital of Traditional Chinese Medicine from October 1,2021 to September 30,2023 were selected as the research subjects.42 patients in the control group were given oral domperidone tablets and lifestyle coordination on the basis of conventional western medicine hypoglycemic treatment,and 42 patients in the treatment group were given oral treatment of Shenzhi Hewei recipe on the basis of the treatment of the control group.The total efficacy,TCM syndrome symptom score scale,Pittsburgh sleep quality index scale,anxiety self-rating scale,depression self-rating scale,gastrin-17,gastric emptying time,fasting blood sugar,2h postprandial blood sugar,and glycosylated hemoglobin were observed before and after treatment in the two groups of patients,and the efficacy indicators of the two groups were compared and analyzed.Results:The total effective rate of the treatment group was 97.6%(41/42),significantly better than 83.3%(35/42)of the control group(P<0.05).After treatment,the TCM syndrome symptom score,Pittsburgh Sleep Quality Index,Anxiety Self-rating Scale,Depression Self-rating Scale,gastrin-17,gastric emptying time,fasting blood sugar,2h postprandial blood sugar,and glycosylated hemoglobin of the treatment group were all lower than those before treatment and lower than those of the control group after treatment(P<0.05).Conclusion:Shenzhi Hewei recipe has a definite clinical effect on patients with DGP of Qi and Yin deficiency and stasis type,and can effectively improve gastrointestinal discomfort symptoms of DGP patients,improve patients’sleep quality,reduce the risk of anxiety and depression,and effectively regulate patients’gastrointestinal hormones and gastric emptying time,which is worthy of clinical application and promotion.