双歧杆菌三联活菌胶囊联合诺氟沙星和蒙脱石散治疗急性细菌性腹泻患者的效果

Effects of Bifidobacterium triple viable capsule combined with Norfloxacin and Montmorillonite powder in treatment of patients with acute bacterial diarrhea

目的:观察双歧杆菌三联活菌胶囊联合诺氟沙星和蒙脱石散治疗急性细菌性腹泻患者的效果。方法:选取2021年9月至2023年5月该院收治的94例急性细菌性腹泻患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各47例。对照组采用诺氟沙星胶囊联合蒙脱石散治疗,研究组在对照组基础上联合双歧杆菌三联活菌胶囊治疗。比较两组临床疗效、症状消失时间、住院时间、治疗前后血清炎性因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、淀粉样蛋白(SAA)]水平,以及不良反应发生率。结果:研究组治疗总有效率为95.74%(45/47),高于对照组的80.85%(38/47),差异有统计学意义(P<0.05);研究组腹痛消失时间、大便性状复常时间、大便次数复常时间及住院时间均短于对照组,差异有统计学意义(P<0.05);治疗5 d后,研究组血清CRP、PCT、IL-6、SAA水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双歧杆菌三联活菌胶囊联合诺氟沙星和蒙脱石散治疗急性细菌性腹泻患者可提高治疗总有效率,加快临床症状消失,缩短住院时间,降低炎性因子水平,效果优于诺氟沙星联合蒙脱石散治疗。

Objective:To observe effects of Bifidobacterium triple viable capsule combined with Norfloxacin and Montmorillonite powder in treatment of patients with acute bacterial diarrhea.Methods:A prospective study was conducted on 94 patients with acute bacterial diarrhea admitted to the hospital from September 2021 to May 2023.According to the random number table method,they were divided into study group and control group,47 cases in each group.The control group was treated with Norfloxacin capsules combined with Montmorillonite powder,while the study group was treated with Bifidobacterium triple viable capsule on the basis of the control group.The clinical efficacy,the symptom disappearance time,the hospitalization time,the serum inflammatory factor[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),amyloid protein(SAA)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.74%(45/47),which was higher than 80.85%(38/47)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of abdominal pain,the recovery time of stool traits,the recovery time of stool frequency and the hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After 5 days of treatment,the levels of serum CRP,PCT,IL-6 and SAA in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bifidobacterium triple viable capsule combined with Norfloxacin and Montmorillonite powder is effective in the treatment of the patients with acute bacterial diarrhea,which can improve the total effective rate of treatment,accelerate the disappearance of clinical symptoms,shorten the hospitalization time and reduce the levels of inflammatory factors.Moreover,it is superior to Norfloxacin combined with Montmorillonite powder treatment.