生血宝颗粒联合多糖铁复合物治疗妊娠期缺铁性贫血患者的效果

Effects of Shengxuebao granules combined with Polysaccharide-iron complex in treatment of patients with iron deficiency anemia during pregnancy

目的:观察生血宝颗粒联合多糖铁复合物治疗妊娠期缺铁性贫血患者的效果。方法:选取2022年10月至2024年1月该院收治的82例妊娠期缺铁性贫血患者进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各41例。对照组予以多糖铁复合物治疗,观察组在对照组基础上联合生血宝颗粒治疗,两组均连续治疗1个月。比较两组临床疗效,治疗前后红细胞参数[血红蛋白(Hb)、红细胞分布宽度(RDW)、平均红细胞血红蛋白含量(MCH)、平均红细胞体积(MCV)]、铁代谢指标[血清铁(SI)、血清铁蛋白(SF)]水平,不良反应发生率,以及不良母婴结局发生率。结果:观察组治疗总有效率为90.24%(37/41),高于对照组的70.73%(29/41),差异有统计学意义(P<0.05);治疗后,观察组Hb、MCH、MCV、SI、SF水平高于对照组,RDW水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组不良母婴结局发生率为4.88%(2/41),低于对照组的19.51%(8/41),差异有统计学意义(P<0.05)。结论:生血宝颗粒联合多糖铁复合物治疗妊娠期缺铁性贫血患者可提高治疗总有效率,改善红细胞参数水平,提高铁代谢指标水平,降低不良母婴结局发生率,效果优于单纯多糖铁复合物治疗。

Objective:To observe effects of Shengxuebao granules combined with Polysaccharide-iron complex in treatment of patients with iron deficiency anemia during pregnancy.Methods:A prospective study was conducted on 82 patients with iron deficiency anemia during pregnancy admitted to the hospital from October 2022 to January 2024.According to the random number table method,they were divided into control group and observation group,41 cases in each group.The control group was treated with Polysaccharide-iron complex,while the observation group was treated with Shengxuebao granules on the basis of that of the control group.Both groups were treated continuously for 1 month.The clinical efficacy,the levels of erythrocyte parameters[hemoglobin(Hb),red blood cell distribution width(RDW),mean corpuscular hemoglobin(MCH),mean corpuscular volume(MCV)]and the iron metabolism indexes[serum iron(SI),serum ferritin(SF)],the incidence of adverse reactions,and the incidence of adverse maternal and infant outcomes were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 90.24%(37/41),which was higher than 70.73%(29/41)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Hb,MCH,MCV,SI and SF in the observation group were higher than those in the control group,the RDW level was lower than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of adverse maternal and infant outcomes in the observation group was 4.88%(2/41),which was lower than 19.51%(8/41)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Shengxuebao granules combined with Polysaccharide-iron Complex in the treatment of the patients with iron deficiency anemia during pregnancy can improve the total effective rate of treatment,improve the levels of erythrocyte parameters,improve the levels of iron metabolism indexes,and reduce the incidence of adverse maternal and infant outcomes.Moreover,it is superior to single Polysaccharide-iron complex treatment.