乳腺癌组织HER-2、Ki67表达水平及其与病理参数的相关性

Correlations among expression levels of HER-2 and Ki67 and pathological parameters in breast cancer tissues

目的:分析乳腺癌组织人表皮生长因子受体-2(HER-2)、细胞增殖核抗原(Ki67)表达水平及其与病理参数的相关性。方法:回顾性分析2021年9月至2023年4月该院收治的70例乳腺癌患者的临床资料,采用免疫组织化学染色法检测患者癌组织HER-2、Ki67表达水平,比较不同病理参数乳腺癌患者癌组织HER-2、Ki67表达水平,并分析其与病理参数的相关性。结果:70例乳腺癌患者中,癌组织HER-2阳性54例,阳性率为77.14%(54/70);Ki67阳性47例,阳性率为67.14%(47/70);不同年龄、病理类型乳腺癌患者癌组织HER-2、Ki67阳性率比较,差异均无统计学意义(P>0.05);不同淋巴结转移、临床分期、肿瘤直径乳腺癌患者癌组织HER-2、Ki67阳性率比较,差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,乳腺癌组织HER-2、Ki67表达水平与淋巴结转移、临床分期、肿瘤直径均呈正相关(r>0,P<0.05)。结论:乳腺癌组织HER-2、Ki67表达水平与淋巴结转移、临床分期、肿瘤直径均呈正相关。

Objective:To analyze correlations of expression levels of human epidermal growth factor receptor-2(HER-2)and proliferating cell nuclear antigen(Ki67)and pathological parameters in breast cancer tissues.Methods:The clinical data of 70 patients with breast cancer admitted to this hospital from September 2021 to April 2023 were retrospectively analyzed.The expression levels of HER-2 and Ki67 in the cancer tissues were detected by immunohistochemical staining.The expression levels of HER-2 and Ki67 in cancer tissues of the breast cancer patients with different pathological parameters were compared.The correlations among the expression levels of HER-2 and Ki67 and the pathological parameters were analyzed.Results:Among the 70 patients with breast cancer,54 cases were positive for HER-2 in the cancer tissues,with a positive rate of 77.14%(54/70);and Ki67 was positive in 47 cases,with a positive rate of 67.14%(47/70).There were no significant differences in the positive rates of HER-2 and Ki67 in the cancer tissues of the breast cancer patients with different ages and pathological types(P>0.05).There were significant differences in the positive rates of HER-2 and Ki67 in the breast cancer tissues of the patients with different lymph node metastasis,clinical stage and tumor diameter(P<0.05).Pearson correlation analysis showed that the expression levels of HER-2 and Ki67 in the breast cancer tissues were positively correlated with lymph node metastasis,clinical stage and tumor diameter(r>0,P<0.05).Conclusions:The expression levels of HER-2 and Ki67 in the breast cancer tissues are positively correlated with lymph node metastasis,clinical stage and tumor diameter.