血清Myo、cTnI、NT-proBNP、心肌酶谱水平联合检测在心肌梗死诊断中的价值

Value of combined detection of serum Myo,cTnI,NT-proBNP and myocardial enzymes in diagnosis of myocardial infarction

目的:分析血清肌红蛋白(Myo)、肌钙蛋白I(cTnI)、N-末端脑钠肽前体(NT-proBNP)、心肌酶谱[肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、肌酸激酶(CK)]水平联合检测在心肌梗死诊断中的价值。方法:选取2021年5月至2023年5月郑州市惠济区人民医院收治的78例心肌梗死患者进行横断面研究,设为观察组;选取同期该院收治的78例冠心病非心肌梗死患者进行横断面研究,设为对照组。比较两组血清Myo、cTnI、NT-proBNP、CK-MB、LDH、CK水平;采用受试者工作特征(ROC)曲线分析血清Myo、cTnI、NT-proBNP、CK-MB、LDH、CK水平单项及联合检测诊断心肌梗死的价值。结果:观察组血清Myo、cTnI、NT-proBNP、CK-MB、LDH、CK水平均高于对照组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清Myo、cTnI、NT-proBNP、CK-MB、LDH、CK水平单项及联合检测诊断心肌梗死的曲线下面积(AUC)分别为0.700、0.750、0.780、0.846、0.600、0.869、0.923,均有一定的诊断价值,其中联合检测的诊断价值高于六者单项检测诊断。结论:血清Myo、cTnI、NT-proBNP、CK-MB、LDH、CK水平联合检测诊断心肌梗死的价值高于六者单项检测诊断。

Objective:To observe value of combined detection of serum myoglobin(Myo),cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP),myocardial zymogram[creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),creatine kinase(CK)]levels in diagnosis of myocardial infarction.Methods:A cross-sectional study was conducted on 78 patients with myocardial infarction admitted to Zhengzhou Huiji District People’s Hospital from May 2021 to May 2023,and they were set as the observation group.A cross-sectional study was conducted on 78 patients with coronary heart disease and non-myocardial infarction admitted to the hospital during the same period,and they were set as the control group.The levels of serum Myo,cTnI,NT-proBNP,CK-MB,LDH and CK were compared between the two groups.ROC curve was used to analyze the values of single and combined detection of serum Myo,cTnI,NT-proBNP,CK-MB,LDH and CK levels in the diagnosis of myocardial infarction.Results:The levels of serum Myo,cTnI,NT-proBNP,CK-MB,LDH and CK in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the areas under the curve(AUC)of single and combined detection of serum Myo,cTnI,NT-proBNP,CK-MB,LDH and CK levels in the diagnosis of myocardial infarction were 0.700,0.750,0.780,0.846,0.600,0.869 and 0.923,separately,which had certain diagnostic value.The diagnostic value of combined detection was higher than that of single detection.Conclusions:The value of combined detection of serum Myo,cTnI,NT-proBNP,CK-MB,LDH and CK levels in the diagnosis of myocardial infarction is higher than that of single detection.