芳基硫酸酯酶A在帕金森病发病中的作用机制研究进展

Research Progress of Role of Arylsulfatase A in Pathogenesis of Parkinson′s Disease

帕金森病(PD)是第二大常见的神经退行性疾病,主要影响中枢神经系统的多巴胺神经元。目前其确切病因不明,尚无有效疗法,科研人员致力于寻找PD早期诊断生物标志物及其早期干预措施,以减缓或阻止PD进展。芳基硫酸酯酶A(ARSA)作为溶酶体基因编码的水解酶,其结构和功能及水平改变与PD的发生发展密切相关,因此,血浆ARSA水平可作为评价PD及其严重程度的潜在生物标志物。未来深入研究ARSA在PD发病中的可能作用机制,可为PD的防治提供新思路。

Parkinson′s disease(PD)is the second most common neurodegenerative disease,mainly affecting dopamine neurons in the central nervous system.The exact cause is unknown,and there is no effective treatment for PD.The researchers are committed to find early diagnostic biomarkers for PD and early interventions to slow down or prevent the progression of PD.Arylsulfatase A(ARSA),as a hydrolase enzymes encoded by lysosomal genes,its structure,function and level changes are closely related to the occurrence and development of PD.Therefore,ARSA plasma level can be used as a potential biomarker to evaluate PD and its severity.Further study of the possible mechanism of ARSA in the pathogenesis of PD can provide new ideas for the prevention and treatment of PD.