慢性肾脏病患者衰弱评估的研究进展

Research Progress in Frailty Assessment of Patients with Chronic Kidney Disease

近年来,衰弱已经成为医学领域的研究热点,慢性肾脏病患者存在毒素蓄积、营养物质丢失、酸碱代谢紊乱和慢性微炎症等共病状态,促进了衰弱的发生发展。但目前衰弱的评估和诊断工具缺乏一致性,测量方法和操作性定义也存在差异性。基于慢性肾脏病患者衰弱的定义、危险因素及评估工具和方法认识各评估工具的应用情况、优势及局限,有助于早期识别慢性肾脏病衰弱,并为构建有效干预措施提供参考。

In recent years,frailty has become a research hotspot in the medical field.Patients with chronic kidney disease have comorbidities such as toxin accumulation,nutrient loss,acid-base metabolism disorders,and chronic micro-inflammation,which promote the occurrence and development of frailty.However,the current assessment and diagnostic tools for frailty lack consistency,and there are differences in measurement methods and operational definitions.Understanding the application,advantages and limitations of various assessment tools based on the definition,risk factors and assessment tools and methods of frailty in patients with chronic kidney disease can help identify the frailty early and provide reference for constructing effective intervention measures.