肠外营养相关性肝病研究进展

Research progress of parenteral nutrition-associated liver disease

肠外营养相关性肝病(PNALD)是指接受全肠外营养患者出现的一系列肝病,从肝酶异常到脂肪变性,再到纤维化,直至最终出现肝硬化。PNALD的发病机制是多因素的,目前尚不完全清楚。PNALD没有具体的治疗方法,其预防和治疗的管理策略取决于对危险因素的了解。本文就PNALD的发病机制和治疗进展进行综述。

Parenteral nutrition-associated liver disease(PNALD)refers to a range of liver diseases that occur in patients who receive total parenteral nutrition,ranging from abnormal liver enzymes to steatosis,fibrosis,and eventually cirrhosis.The pathogenesis of PNALD is multifactorial and is not completely understood.There is no specific treatment for PNALD,and management strategies for its prevention and treatment depend on knowledge of the risk factors.This article reviews the pathogenesis and treatment progress of PNALD.