HDAC11参与调控哺乳动物卵母细胞成熟及早期胚胎发育的研究进展

Progress on the involvement of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development

卵母细胞成熟和早期胚胎发育是雌性哺乳动物生殖生理过程的关键步骤,该过程中出现任何差错都会对生殖发育产生不利影响。新近研究表明,组蛋白的表观修饰对卵母细胞减数分裂调控及早期胚胎发育的质量保证等均具有重要作用。组蛋白去乙酰化酶11(histone deacetylase 11,HDAC11)是目前已知最小的组蛋白去乙酰化酶(histone deacetylases,HDACs)家族成员,抑制HDAC11活性显著降低卵母细胞成熟率以及胚胎期8细胞和囊胚的发育率。本文重点综述了HDAC11在调控哺乳动物卵母细胞成熟及早期胚胎发育中重要作用的研究进展,以期深入了解以HDAC11为代表的表观修饰蛋白在哺乳动物生殖调控中发挥的关键作用及其分子机制。

Oocyte maturation and early embryonic development are key steps in the reproductive physiology of female mammals,and any error in this process can adversely affect reproductive development.Recent studies have shown that epigenetic modifications of histones play important roles in the regulation of oocyte meiosis and quality assurance of early embryonic development.Histone deacetylase 11(HDAC11)is the smallest known member of the histone deacetylases(HDACs)family,and inhibition of HDAC11 activity significantly suppresses the rate of oocyte maturation,as well as the development of 8-cell and blastocyst embryos at the embryonic stage.This paper focuses on recent progress on the important role of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development,hoping to gain insights into the key roles played by epitope-modifying proteins represented by HDAC11 in the regulation of mammalian reproduction and their molecular mechanisms.