代谢重编程对腹主动脉瘤的影响

Effect of metabolic reprogramming on abdominal aortic aneurysm

腹主动脉瘤(abdominal aortic aneurysm,AAA)早期起病隐匿,急性破裂时常危及患者生命。目前,AAA缺乏有效的药物治疗手段,深入探索其发病机制成为解决问题的关键。代谢重编程是细胞为满足自身物质和能量需要而改变代谢模式的过程,主要包括糖代谢、脂质代谢和氨基酸代谢三个方面,其在心血管疾病尤其是AAA中的调节作用近年来备受关注。本文聚焦近年血管平滑肌细胞(vascular smooth muscle cells,VSMCs)和巨噬细胞的代谢重编程对AAA发生、发展的影响的研究进展,特别是其在VSMCs凋亡和表型转化、细胞外基质重塑、氧化应激和炎症反应等主要病理过程中的作用,以期从代谢角度为AAA的机制研究和临床治疗提供新思路。

Abdominal aortic aneurysm(AAA)is a life-threatening disease that remains undetected until it acutely ruptures.Due to lack of effective pharmaceutic therapies,it is urgent to explore new prevention and treatment strategies.Metabolic reprogramming is a cellular process through which cells change their metabolic patterns to meet material and energy requirements,including glucose metabolism,lipid metabolism and amino acid metabolism.Recently,the regulatory role of metabolic reprogramming in cardiovascular diseases,especially AAA,has attracted significant attention.This review article focuses on the research progress regarding the effects of metabolic reprogramming of vascular smooth muscle cells(VSMCs)and macrophages on the occurrence and development of AAA,especially their roles in major pathological processes such as VSMCs apoptosis and phenotype transformation,extracellular matrix remodeling,oxidative stress,and inflammatory response.The aim is to provide new clues for the mechanism research and clinical treatment of AAA from the perspective of metabolism.