静电植绒促凝血织物的构建及其性能评价

Construction and performance evaluation of electrostatic flocking procoagulant fabric

通过多巴胺原位聚合改性,显著提高传统医用纤维的导电性,结合静电植绒技术构建PET@PDA植绒织物;采用响应面法优化植绒工艺参数,建立了植绒工艺参数和植绒密度、植绒比表面积的回归模型;系统评价PET@PDA植绒织物的表观形貌、力学性能、细胞相容性和血液相容性。研究结果表明:PET@PDA10-2植绒织物的植绒垂直取向度高、孔隙率大、压缩回复性能优异,在50%应变下的压缩回复率98.10%;同时还具有良好的细胞相容性、血液相容性及优异的促凝血能力。因此,所制备的PET@PDA静电植绒织物在止凝血材料方面具有一定的应用潜力。

The electrical conductivity of traditional medical fibers was enhanced through in-situ polymerization of dopamine,resulting in the fabrication of a PET@PDA flocking fabric using electrostatic flocking technology.The response surface methodology was employed to optimize the parameters of the flocking process,and regression models were established to analyze the relationship between flocking process parameters and flocking density,specific surface area.An evaluation was conducted on the appearance,mechanical properties,cell compatibility,and blood compatibility of PET@PDA flocked fabric.The results demonstrate that PET@PDA10-2 flocking fabric exhibits high vertical orientation,significant porosity,excellent compression recovery performance(98.10% recovery rate under 50% strain),as well as favorable cytocompatibility and blood compatibility with remarkable coagulant promoting ability.Therefore,the electrostatically flocked PET@PDA fabric holds promising potential for applications in anticoagulant materials.