30%超分子水杨酸联合低能量强脉冲光治疗中、重度面部痤疮疗效观察

Efficacy of 30%supramolecular salicylic acid combined with intense pulsed light in the management of moderate to severe facial acne

目的:了解30%超分子水杨酸凝胶联合强脉冲光治疗中、重度面部痤疮的临床疗效。方法:选取2021年1月至2023年1月某院门诊经治面部中、重度痤疮患者60例,采用抽签法将所有患者均分为对照组与观察组,对照组仅给予常规治疗方案,观察组除常规治疗方案外,加用30%超分子水杨酸凝胶联合强脉冲光,两组均治疗8周,依据治疗前及末次治疗4周后皮损照片对比情况评估皮损改善情况。于治疗前及末次治疗4周后分别采用痤疮瘢痕ECCA评分量表、皮肤病生活质量指数(DLQI)对两组患者面部瘢痕及生活质量进行评估,记录两组患者治疗过程中红肿、烧灼感、水疱、色素沉着、感染等不良反应的发生情况,对所有数据进行统计学分析。结果:观察组痊愈率及总有效率均显著高于对照组(P均<0.05)。两组治疗后ECCA评分及DLQI评分均低于治疗前(P均<0.05)。观察组治疗后ECCA评分及DLQI评分均低于对照组(P均<0.05)。两组治疗相关红肿、水疱、色素沉着及感染发生率间差异均无统计学意义(P均>0.05)。观察组治疗相关烧灼感发生率高于对照组(P<0.05)。结论:30%超分子水杨酸凝胶联合强脉冲光治疗可显著改善中、重度面部痤疮皮损,减轻痤疮瘢痕,提高患者生活质量且安全性良好。

Objective:To learn the efficacy of 30%supramolecular salicylic acid(SSA)combined with intense pulsed light(IPL)in the management of moderate to severe facial acne.Methods:60 cases of moderate to severe facial acne treated in our clinic from I anuary 2021 to January 2023 were included and divided equally into two groups,the control group and the observation group,according to the lottery method.The control group was treated with a common medicational strategy for 8 weeks,while the observation group was given additional SSA and IPL.We can evaluate the improvement of lesions based on the lesion pictures taken before treatment and 4 weeks after the last treatment.We can assess the progress of the facial acne scar and the quality of life based on the ECCA grading scale and dermatology life quality index(DLQI),evaluated before and 4 weeks after the last treatment.Record the adverse events during treatment,such as edema,burning sensation,bullous,hyperpigmentation,infection,et al.Statistical analyses were performed according to all data.Results:The cure rate and total efficacy rate of the observation group were higher than those of the control group(P<0.05).The ECCA score and DLQI score of both groups after treatment were lower than those before treatment(P<0.05).The ECCA score and DLQI score of the observation group were lower than those of the control group(P<0.05).The incidence of edema,bullous,byperpigmentation,and infection between both groups had no significant difference(P>0.05).The incidence of burning sensation in the observation group was higher than that of the control group(P<0.05).Conclusion:In managing moderate to severe facial acne,30%SSA combined with IPL can improve the lesions,mitigate the acne scars,and improve quality of life with reasonable safety.