针刺防治血管性痴呆作用机制研究进展

Research Progress on Action Mechanism of Acupuncture in Preventing and Treating Vascular Dementia

VD是一种由于脑血管病变导致的认知功能障碍综合征,目前被认为是唯一有可能预防的痴呆类型。研究表明,针刺防治VD具有肯定的疗效,能够明显改善患者认知功能、学习和记忆能力等,且与口服药物治疗相比具有副作用小的优势,但其作用机制尚有待探讨。本研究梳理近年来针刺防治VD的相关文献,发现针刺可能通过改善炎症反应、氧化应激、中枢胆碱能神经通路障碍与中枢神经兴奋性毒性等作用机制对VD起治疗作用。

VD is a cognitive dysfunction syndrome caused by cerebrovascular disease,and is currently considered the only possible type of dementia that can be prevented.Research has shown that acupuncture has a definite therapeutic effect on the prevention and treatment of VD,which can significantly improve patients' cognitive function,learning and memory abilities,and has the advantage of fewer side effects compared to oral medication.However,its action mechanism still needs to be explored.This study reviewed relevant literature on acupuncture for the prevention and treatment of VD in recent years,and it is found that acupuncture can treat VD through possible mechanisms including improving inflammatory response,oxidative stress,central cholinergic pathway disorders,and central nervous system excitatory toxicity.