摘要
Comprehensive Summary An asymmetric synthesis of dihydrospirotryprostatin B was achieved in 15 steps(8 purifications)from L-tryptophan.The main feature of our synthetic strategy is the efficient construction of spirocyclic oxindole intermediate containing a chiral quaternary carbon center,involving the silica gel-mediated cyclization of tryptamine-ynamide and oxidation under neat conditions.
基金
the National Natural Science Foundation of China(22277082)
Liaoning Province Education Administration of China(LJKQz2022236)
Liaoning Provincial Foundation of Natural Science(2022-MS-245)
China Postdoctoral Science Foundation(2022MD723807)for financial support.
